Integrated research facility at fort detrick

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Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Project Description:
For FY09, the Integrated Research Facility in the Division of Clinical Research has significantly increased the level of research facilitation that it provides. Primarily, this support has been directed to facilitating the biodefense and emerging infectious disease research of the Emerging Viral Pathogens section in the Division of Intramural Research. Project 1: Viral pathogenesis of orthopoxviruses and development of countermeasures against infection: Introduction and Objectives 1) Characterize monkeypox virus infection of nonhuman primates by the intravenous and intrabronchial route. 2) Determine if cowpox virus infection of nonhuman primates could serve as a BSL-2 model of orthopoxvirus infection. 3) Determine the efficacy of mitoxantrone against cowpox virus in vivo. Project 2: Viral pathogenesis of simian hemorrhagic fever virus: Introduction and Objectives 1) To characterize the pathogenesis of simian hemorrhagic fever virus in nonhuman primates. Project 3: Identification of cell-surface receptors of viral entry:1) Identification of cell-surface receptors for NIAID Priority Pathogens.2) Identification of the cell-surface receptor of simian hemorrhagic fever virus.3) Characterization of the role of filoviral secreted glycoproteins in filovirus cell entry.Project 4: Develop methods for medical imaging of infectious disease:1) Development of tracers for orthopox viruses and filoviruses.
Project Terms:
animal model biodefense biological cell surface receptors cells centers for disease control and prevention (u.s.) clinical clinical research communicable diseases containment cowpox virus development disease emerging communicable diseases filovirus glycoproteins improved in vivo infection infectious diseases research intramural research intravenous laboratories maryland medical medical imaging medical research methods mission mitoxantrone modeling monkey hemorrhagic disease virus monkeypox virus national institute of allergy and infectious disease nonhuman primate novel orthopoxvirus outcome pathogen pathogenesis patients programs public health medicine (field) research research facility research institute research project grants role route science tool tracer united states united states national institutes of health vaccines viral viral pathogenesis virus virus diseases biodefense - biodefense research biodefense - biodefense research - basic research (genomics and pathogenesis) emerging infectious diseases small pox infectious diseases
Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Organization: Niaid Extramural Activities, United States
Principal Investigators (PI): Jahrling Peter, US
Project Categories:
Natural Sciences
Other Information:
Fiscal Year: 2009
Project Start Date: 1 January 2009
Project End Date: 31 December 2009
Project Funding Information:
Funding Mechanism: Intramural Research
Year Funding Organization Total Funding, $
2009 NIH - National Institute Of Allergy And Infectious Diseases $34,269,307
Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Title FY Funding
There are no results for this project in database.
Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Title Journal Year Country Rel
The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection. PLoS Negl Trop Dis 2017 united states
High dose sertraline monotherapy fails to protect rhesus macaques from lethal challenge with Ebola virus Makona. Sci Rep 2017 england
Nonhuman Primate Models of Ebola Virus Disease. Curr Top Microbiol Immunol 2017 germany
Animal Models of Ebolavirus Infection. Comp Med 2017 united states
Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication. MBio 2016 united states
An Inactivated Rabies Virus-Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models. J Infect Dis 2016 united states
Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals. Biol Direct 2016 england
Divergent Simian Arteriviruses Cause Simian Hemorrhagic Fever of Differing Severities in Macaques. MBio 2016 united states
Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Sci Transl Med 2016 united states
Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease. J Gen Virol 2016 england
3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012. Virology 2016 united states
Natural History of Aerosol Exposure with Marburg Virus in Rhesus Macaques. Viruses 2016 switzerland
Specific Detection of Two Divergent Simian Arteriviruses Using RNAscope In Situ Hybridization. PLoS One 2016 united states
Within-host evolution of simian arteriviruses in crab-eating macaques. J Virol 2016 united states
Historical Outbreaks of Simian Hemorrhagic Fever in Captive Macaques Were Caused by Distinct Arteriviruses. J Virol 2015 united states
Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease. Virology 2015
Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway. J Virol 2015 united states
Inactivation and safety testing of Middle East Respiratory Syndrome Coronavirus. J Virol Methods 2015 netherlands
Use of existing diagnostic RT-PCR assays for detection of Ebola virus RNA in semen. J Infect Dis 2015
Lack of effect of lamivudine on Ebola virus replication. Emerg Infect Dis 2015 united states
Evaluation of candidate vaccine approaches for MERS-CoV. Nat Commun 2015 england
State-of-the-Art Workshops on Medical Countermeasures Potentially Available for Human Use Following Accidental Exposures to Ebola Virus. J Infect Dis 2015
Generation and characterization of large-particle aerosols using a center flow tangential aerosol generator with a non-human-primate, head-only aerosol chamber. Inhal Toxicol 2015 england
Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrob Agents Chemother 2014 united states
ABSL-4 aerobiology biosafety and technology at the NIH/NIAID integrated research facility at Fort Detrick. Viruses 2014 switzerland
Genome Sequences of Simian Hemorrhagic Fever Virus Variant NIH LVR42-0/M6941 Isolates (Arteriviridae: Arterivirus). Genome Announc 2014 united states
Two novel simian arteriviruses in captive and wild baboons (Papio spp.). J Virol 2014 united states
Interferon-? and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays. J Gen Virol 2014 england
Systems kinomics for characterizing host responses to high-consequence pathogens at the NIH/NIAID Integrated Research Facility-Frederick. Pathog Dis 2014 united states
CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory syndrome coronavirus (MERS-CoV) infection and evolution of persistent infection. PLoS One 2014 united states
The effect of volume of interest definition on quantification of lymph node immune response to a monkeypox virus infection assessed by (18)F-FDG-PET. EJNMMI Res 2014 germany
Reidentification of Ebola Virus E718 and ME as Ebola Virus/H.sapiens-tc/COD/1976/Yambuku-Ecran. Genome Announc 2014 united states
Variola virus archives: a new century, a new approach. Lancet 2014 england
Nomenclature- and database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014. Viruses 2014 switzerland
Antibody quality and protection from lethal Ebola virus challenge in nonhuman primates immunized with rabies virus based bivalent vaccine. PLoS Pathog 2013 united states
Comparative pathology of smallpox and monkeypox in man and macaques. J Comp Pathol 2013 england
Nonhuman transferrin receptor 1 is an efficient cell entry receptor for Ocozocoautla de Espinosa virus. J Virol 2013 united states
The International Code of Virus Classification and Nomenclature (ICVCN): proposal for text changes for improved differentiation of viral taxa and viruses. Arch Virol 2013 austria
Poxvirus antigen staining of immune cells as a biomarker to predict disease outcome in monkeypox and cowpox virus infection in non-human primates. PLoS One 2013 united states
Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system. PLoS Pathog 2013 united states
Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae. Arch Virol 2013 austria
Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection. PLoS One 2012 united states
Clinical management of filovirus-infected patients. Viruses 2012 switzerland
Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses. Expert Opin Drug Discov 2012 england
Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone. Antiviral Res 2012 netherlands
Intrabronchial inoculation of cynomolgus macaques with cowpox virus. J Gen Virol 2012 england
Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Title Year
Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Title Phase Year