Prenatal diagnosis trials--fetal cells/maternal blood

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Project Title: Prenatal diagnosis trials--fetal cells/maternal blood
Principal Investigators (PI): SHULMAN LEE P
Project Number: N01HD043203-009
Organization: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
 
Project Description:
This project represents phase II of a projeCt whose main objective is to develop a non-invasive, safe, relatively inexpensive and accurate technique for the prenatal diagnosis of genetic disorders that can be performed during the first trimester. Phase II will test, expand and refine the methodology developed in phase I. The study will include a systematic evaluation of the variables involved in separating and enriching fetal cells from maternal blood through flow cytometry or other methods, including magnetic-activated cell sorting (MACS), followed by in situ hybridization with chromosome-specific DNA probes. The results of these peripheral blood studies will be compared to those that will be obtained from amniocentesis or chorionic villus sampling (CVS) on the same women. Another objective of the project is to determine whether or not there are any non-biological effects on the women undergoing prenatal diagnostic testing. Even if the biologic risks associated with reproductive genetic technologies are reduced, the possibility exists that other potential risks (or benefits) are associated with the procedures. Some of these factors may be: expanded or diminished maternal anxiety, increased adjustment or maladaptation to the pregnancy, increased feelings of coercion to undertake prenatal testing when there are negligible biologic risks associated with the procedure, and increased or decreased comfort with reproductive decision-making.
 
Project Terms:
pregnancy circulation prenatal diagnosis genetic disorder diagnosis embryo /fetus cell /tissue diagnosis design /evaluation nucleic acid probes sex chromosomes fluorescent dye /probe clinical trials noninvasive diagnosis chromosome aberrations chorionic villus sampling flow cytometry amniocentesis in situ hybridization human subject
Project Title: Prenatal diagnosis trials--fetal cells/maternal blood
Principal Investigators (PI): SHULMAN LEE P
Project Number: N01HD043203-009
Organization: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
 
Project Categories:
• Natural Sciences > Experimental techniques, Aging Diseases and Pathology > in vitro methods, Cardiovascular and cerebrovascular diseases > Flow cytometry, Heart failure
 
Other Information:
Fiscal Year: 1994
Project Start Date: 1 March 1994
Project End Date: 31 October 1999
Administering Institute Or Center: HD
 
Project Funding Information:
Total Funding: $600,000
Year Funding Organization Total Funding, $
2000 EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT $600,000
Project Title: Prenatal diagnosis trials--fetal cells/maternal blood
Principal Investigators (PI): SHULMAN LEE P
Project Number: N01HD043203-009
Organization: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Prenatal diagnosis trials--fetal cells/maternal blood
Principal Investigators (PI): SHULMAN LEE P
Project Number: N01HD043203-009
Organization: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
 
Project number Project title Organization FY Funding Organization FY Total Cost
N01HD043203-009PRENATAL DIAGNOSIS TRIALS--FETAL CELLS/MATERNAL BLOODUNIVERSITY OF TENNESSEE HEALTH SCI CTR2000EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
$600,000
Project Title: Prenatal diagnosis trials--fetal cells/maternal blood
Principal Investigators (PI): SHULMAN LEE P
Project Number: N01HD043203-009
Organization: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Prenatal diagnosis trials--fetal cells/maternal blood
Principal Investigators (PI): SHULMAN LEE P
Project Number: N01HD043203-009
Organization: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
 
Title Abstract Authors Year Rel