Age-related eye disease study 2 (areds2) coordinating center

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Project Title: Age-related eye disease study 2 (areds2) coordinating center
Principal Investigators (PI): CLEMONS TRACI
Project Number: N01EY50007-13-0-1
Organization: EMMES CORPORATION
 
Project Description:
Purpose: To study the effects of high supplemental doses of dietary xanthophylls (lutein and zeaxanthin)and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)(DHA and EPA)on the development of advanced AMD. To study the effects of these supplements on cataract and moderate vision loss. To study the effects of eliminating beta-carotene from the original AREDS formulation on the development and progression of AMD. To study the effects of reducing zinc in the original AREDS formulation on the development and progression of AMD. To contribute data for validation of the photographic AMD scales developed from the Age-Related Eye Disease Study. AREDS 2 is a multi-center randomized trial of 4,000 participants designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and omega-3 LCPUFAs (DHA and EPA) on the progression to advanced AMD. The study will enroll participants aged 50 to 85 years, with sufficiently clear ocular media to allow accurate assessment of AMD from fundus photographs. Participants should have either bilateral large drusen (>125 microns) or large drusen in one eye and advanced AMD in the fellow eye. All participants will be offered additional treatment with the original AREDS formulation (now considered standard of care) and 3 variations of this formula. These are: (1) no beta-carotene;(2) lower amounts of zinc;and (3) no beta-carotene and lower amounts of zinc. Eligible participants will be followed for a minimum of five years.
 
Project Terms:
(3R,3'R)-beta,beta- carotene-3,3'-diol 21+ years old 3,4-didehydroretinal 3-dehydroretinal Accounting Address Adult Adverse Experience Adverse event Advertising Advisory Committees Age related macular degeneration Aged 65 and Over Aging Americas Antioxidants Area Ascorbic Acid Assessment, Process Award Behavioral Beta Carotene Betacarotene Bilateral Biochemical Blindness Blood Vessels Body Tissues Carotene Cataract Cataract Extraction Causality Characteristics Charge Chronic Cicatrix Clinic Clinical Data Clinical Research Clinical Study Clinical Trials Clinical Trials Data Monitoring Committees Clinical Trials Design Clinical Trials, Phase III Clinical Trials, Unspecified Consumption Contracting Opportunities Contractor Contracts Contracts Review Cost Benefit Analyses Cost-Benefit Analysis Cost-Benefit Data Cost/Benefit Analyses Cost/Benefit Analysis Costs and Benefits Country Cross-Product Ratio Data Data Monitoring Committees Data and Safety Monitoring Boards Development Diet Supplement Dietary Supplements Disciform macular degeneration Disciform senile macular retinal degeneration Disease Disorder Dose Drug Formulations Drugs Druse Drusen Early treatment Economics, Cost/Benefit Elderly Elderly, over 65 Electromagnetic, Laser Energy Expenditure Energy Metabolism Enrollment Ensure Environmental Exposure Etiology European Evaluation Exhibits Exudative AMD Exudative age-related macular degeneration Eye Eye diseases Eyeball Fatty Acids, Omega-3 Fatty Acids, Polyunsaturated Formulation Formulations, Drug Fundus Generations Glaucoma Goals Human, Adult Incidence Intake Intervention Intervention Strategies Intervention Trial L-Ascorbic Acid LUT Lasers Lens Opacities Letters Leutin Life Light Logistics Lutein Maculopathy, Age-Related Manuals Manufacturer Manufacturer Name Measures Medication Metabolic Monitor Morphology National Eye Institute Neovascular AMD Neovascular age-related macular degeneration Nervous Nutrient Nutrition Nutritional Science Nutritional Supplement Odds Ratio Omega-3 Fatty Acids Omega-3 PUFA Omega-3 Polyunsaturated Fatty Acid Operation Operative Procedures Operative Surgical Procedures Oral Outcome Outer pigmented layer of retina PBO Participant Pathogenesis Patients Performance Persons Pharmaceutic Preparations Pharmaceutical Preparations Phase Phase 3 Clinical Trials Phase III Clinical Trials Photochemotherapy Photodynamic Therapy Photoradiation Pigment cell layer of retina Pigmented layer of retina Placebos Policies Polyunsaturated Fatty Acids Population Population Study Populations at Risk Prevalence Prevention Preventive Intervention Procedures Process Process Assessment (Health Care) Property Property, LOINC Axis 2 Protocol Protocols documentation Publishing Radiation, Laser Randomized Clinical Trials Relative Odds Reporting Research Research Design Retina Retinal Retinal Diseases Retinal Disorder Retinal Pigment Epithelium Retinal pigment epithelial cells Review Literature Risk Risk Ratio Roche Brand of Betacarotene SCHED Safety Monitoring Boards Scars Schedule Science of nutrition Senescence Sham Treatment Sight Signal Pathway Site Solatene Source Specific qualifier value Specified Structure of retinal pigment epithelium Study Type Supplementation Surgical Surgical Interventions Surgical Procedure System System, LOINC Axis 4 Task Forces Tissues Training Translating Translatings Translational Research Translational Research Enterprise Translational Science United States VIT C Validation Variant Variation Vision Vision research Visual Acuity Vitamin C Vitamin E Wet AMD Work Xanthophyll Carotenoids Xanthophylls Zinc Zn element adult human (21+) advanced age age dependent age related aged anti-oxidant base beta,beta-Carotene beta,epsilon-Carotene-3,3'-diol, (3R,3'R,6'R)- beta-carotene-3,3'-diol cataract surgery cataractogenesis cataractous lenses clinical investigation clinical research site clinical site comparative trial compare effectiveness cost cost benefit economics cost benefit effectiveness data management dehydroretinal design designing discovery mining disease causation disease etiology disease/disorder disease/disorder etiology disorder etiology drug distribution drug/agent economic impact effective therapy elders eligible participant end stage disease enroll evidence base experience eye disorder gamma Lutein geographic atrophy geriatric glaucomatous interventional strategy language translation laser photocoagulation late life later life literature mining literature searching macula macular meetings n-3 Fatty Acids neoplasm/cancer photoradiation therapy neovascular neural nutrition older adult older person omega-3 ophthalmopathy phase 3 study phase 3 trial phase III trial polyunsaturated fatty acid pre-clinical preclinical preventional intervention strategy protocol development protocol, phase III randomized trial relating to nervous system retina disease retina disorder retinal(2) retinopathy routine care senescent senile macular disease senior citizen sham therapy social standard of care study design study, phase III surgery text mining text searching translation research enterprise vascular zeaxanthin
Project Title: Age-related eye disease study 2 (areds2) coordinating center
Principal Investigators (PI): CLEMONS TRACI
Project Number: N01EY50007-13-0-1
Organization: EMMES CORPORATION
 
Project Categories:
• Natural Sciences > Aging Diseases and Pathology > Eye diseases
 
Other Information:
Fiscal Year: 2005
Project Start Date: 30 September 2005
Project End Date: 30 June 2013
Administering Institute Or Center: EY
 
Project Funding Information:
Total Funding: $12,237,012
Year Funding Organization Total Funding, $
2010 NATIONAL EYE INSTITUTE $12,237,012
Project Title: Age-related eye disease study 2 (areds2) coordinating center
Principal Investigators (PI): CLEMONS TRACI
Project Number: N01EY50007-13-0-1
Organization: EMMES CORPORATION
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Age-related eye disease study 2 (areds2) coordinating center
Principal Investigators (PI): CLEMONS TRACI
Project Number: N01EY50007-13-0-1
Organization: EMMES CORPORATION
 
Project number Project title Organization FY Funding Organization FY Total Cost
N01EY50007-13-0-1Age-Related Eye Disease Study 2 (AREDS2) Coordinating CenterEMMES CORPORATION2010NATIONAL EYE INSTITUTE
$12,237,012
Project Title: Age-related eye disease study 2 (areds2) coordinating center
Principal Investigators (PI): CLEMONS TRACI
Project Number: N01EY50007-13-0-1
Organization: EMMES CORPORATION
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Age-related eye disease study 2 (areds2) coordinating center
Principal Investigators (PI): CLEMONS TRACI
Project Number: N01EY50007-13-0-1
Organization: EMMES CORPORATION
 
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