Mitochondrial function as a therapeutic target in muscular dystrophy

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Project Title: Mitochondrial function as a therapeutic target in muscular dystrophy
Principal Investigators (PI): PETROF John
Project Number: CIHR-937113
Organization: Meakins Christie Labs (Quebec)
 
Project Description:
Mitochondria are the most important source of energy generation in muscle cells. In this grant, we propose that impaired mitochondrial function plays a major role in Duchenne muscular dystrophy (DMD). Our goal is to determine if mitochondrial function and overall skeletal muscle health can be improved in mdx mice (model of DMD). The treatment methods will consist of drug therapies, gene therapy, and muscle training exercises. We believe that these treatments are promising because our recently published data indicate better mitochondrial function in the hearts of mdx mice after 6 weeks of treatment with the drug sildenafil (Viagra). In previous studies, improved mitochondrial function has been found in mdx mouse diaphragm muscle after a similar period of muscle training. We will now determine whether these treatments, applied either alone or together, are able to improve abnormal calcium levels, oxidative stress, inflammation, and ultimately muscle strength. Considering the major advantages of pharmacological and training therapies in terms of safety and relative ease of clinical application, these treatments could significantly improve quality of life for DMD patients.
 
Project Terms:
DUCHENNE, DYSTROPHIE MUSCULAIRE, MITOCHONDRIA, MUSCLE PHYSIOLOGY, MUSCLE TRAINING, MUSCLE, BONE, OR JOINT, MUSCLES ET OS, MUSCLES, OS OU ARTICULATIONS, MUSCULAR DYSTROPHY, MUSCULO SKELETAL, OXIDATIVE STRESS
Project Title: Mitochondrial function as a therapeutic target in muscular dystrophy
Principal Investigators (PI): PETROF John
Project Number: CIHR-937113
Organization: Meakins Christie Labs (Quebec)
 
Project Categories:
• Natural Sciences > Model organisms > Multicellular > Frog
 
Other Information:
Fiscal Year: 2009
Project Start Date: 1 October 2009
Project End Date: 30 September 2012
Administering Institute Or Center: CIHR
 
Project Funding Information:
Total Funding: $210,797
Year Funding Organization Total Funding, $
2009 CIHR - Institute of musculoskeletal Health and Arthritis $70,266
2010 CIHR - Institute of musculoskeletal Health and Arthritis $140,531
Project Title: Mitochondrial function as a therapeutic target in muscular dystrophy
Principal Investigators (PI): PETROF John
Project Number: CIHR-937113
Organization: Meakins Christie Labs (Quebec)
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Mitochondrial function as a therapeutic target in muscular dystrophy
Principal Investigators (PI): PETROF John
Project Number: CIHR-937113
Organization: Meakins Christie Labs (Quebec)
 
Project number Project title Organization FY Funding Organization FY Total Cost
CIHR-937109The relationship between proinflammatory mediator expression and diaphragm dysfunctionMeakins Christie Labs (Quebec)2003CIHR - Institute of circulatory and Respiratory Health
$42,075
CIHR-937109The relationship between proinflammatory mediator expression and diaphragm dysfunctionMeakins Christie Labs (Quebec)2004CIHR - Institute of circulatory and Respiratory Health
$84,150
CIHR-937109The relationship between proinflammatory mediator expression and diaphragm dysfunctionMeakins Christie Labs (Quebec)2005CIHR - Institute of circulatory and Respiratory Health
$84,150
CIHR-937109The relationship between proinflammatory mediator expression and diaphragm dysfunctionMeakins Christie Labs (Quebec)2006CIHR - Institute of circulatory and Respiratory Health
$42,075
CIHR-937109The relationship between proinflammatory mediator expression and diaphragm dysfunctionMeakins Christie Labs (Quebec)2007CIHR - Institute of circulatory and Respiratory Health
$116,317
CIHR-937109The relationship between proinflammatory mediator expression and diaphragm dysfunctionMeakins Christie Labs (Quebec)2008CIHR - Institute of circulatory and Respiratory Health
$116,317
CIHR-937109The relationship between proinflammatory mediator expression and diaphragm dysfunctionMeakins Christie Labs (Quebec)2009CIHR - Institute of circulatory and Respiratory Health
$116,317
CIHR-937109The relationship between proinflammatory mediator expression and diaphragm dysfunctionMeakins Christie Labs (Quebec)2010CIHR - Institute of circulatory and Respiratory Health
$116,317
CIHR-937113Mitochondrial function as a therapeutic target in muscular dystrophyMeakins Christie Labs (Quebec)2009CIHR - Institute of musculoskeletal Health and Arthritis
$70,266
CIHR-937113Mitochondrial function as a therapeutic target in muscular dystrophyMeakins Christie Labs (Quebec)2010CIHR - Institute of musculoskeletal Health and Arthritis
$140,531
Project Title: Mitochondrial function as a therapeutic target in muscular dystrophy
Principal Investigators (PI): PETROF John
Project Number: CIHR-937113
Organization: Meakins Christie Labs (Quebec)
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Mitochondrial function as a therapeutic target in muscular dystrophy
Principal Investigators (PI): PETROF John
Project Number: CIHR-937113
Organization: Meakins Christie Labs (Quebec)
 
Title Abstract Authors Year Rel