Cardiovascular control in normal and disease states

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Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 7R37HL033107-17
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project Description:
The major goals of this research proposal are to describe and analyze cardiovascular control mechanisms with particular emphasis on the autonomic nervous system in normal healthy conscious animals, instrumented for direct and instantaneous measurements and radiotelemetry of coronary and regional blood flows and vascular resistances, ventricular function and myocardial contractility. Miniature pressure gauges will be implanted in the left and right ventricles and aorta, ultrasonic dimension transducers will be opposed on the endocardial surfaces of the left ventricle and Doppler ultrasonic or electromagnetic flow probes will be placed on the ascending aorta, coronary, mesenteric, renal and iliac arteries. In order to achieve these goals several specific interlocking groups of projects are planned. First of all, the afferent limb of the autonomic nervous system controlling the circulation will be examined, e.g., regulation by arterial baroreceptors, chemoreceptors, pulmonary inflation receptors, and low pressure vagal afferents. Secondly efferent autonomic control of ventricular performance, the coronary circulation, and the regional circulations will be studied. Thirdly, autonomic control during exercise will be examined. Thus, the aim of this research proposal is to gain a clearer understanding of the control of the cardiovascular system by the autonomic nervous system in the normal conscious animal.
 
Project Terms:
autonomic nervous system heart function hemodynamics cardiovascular disorder nitroglycerin anesthesia baroreceptors vasopressins pentobarbital angiotensin II myocardial ischemia /hypoxia hemorrhage vascular resistance exercise heart circulation heart dimension /size tachycardia myocardial infarction heart contraction kidney circulation cardiac glycosides cardiotonic agents vasoactive agent renin angiotensin system baboons splenectomy dogs telemetry muscle stimulant ultrasound blood flow measurement blood pressure methoxamine isoproterenol
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 7R37HL033107-17
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project Categories:
• Natural Sciences > Aging Diseases and Pathology > Cardiovascular and cerebrovascular diseases > Cerebrovascular disease
 
Other Information:
Fiscal Year: 1984
Project Start Date: 1 January 1983
Project End Date: 30 June 2002
Administering Institute Or Center: HL
 
Project Funding Information:
Total Funding: $624,461
Year Funding Organization Total Funding, $
2000 NATIONAL HEART, LUNG, AND BLOOD INSTITUTE $624,461
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 7R37HL033107-17
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 7R37HL033107-17
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project number Project title Organization FY Funding Organization FY Total Cost
1T32HL069752-01A2Integrative Mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2004NATIONAL HEART
$229,351
5R01HL033107-21Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2004NATIONAL HEART
$650,750
5P01HL059139-07Myocardial Hypertrophy and Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2004NATIONAL HEART
$1,597,506
5R01HL033107-20Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2003NATIONAL HEART
$635,625
2P01HL059139-06Myocardial Hypertrophy and Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2003NATIONAL HEART
$1,451,551
2R01HL033107-19Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2002NATIONAL HEART
$617,111
5P01HL069020-02-0002Mechanisms underlying short term, chronic and true hiberUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2002NATIONAL HEART
$296,386
5R37HL033107-18CARDIOVASCULAR CONTROL IN NORMAL AND DISEASE STATESUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2001NATIONAL HEART
$574,827
5P01HL059139-05MYCARDIAL HYPERTOPHY AND HEART FAILUREUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2001NATIONAL HEART
$1,780,080
7R37HL033107-17CARDIOVASCULAR CONTROL IN NORMAL AND DISEASE STATESUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2000NATIONAL HEART
$624,461
7R01HL033065-15MYOCARDIAL ISCHEMIA AND CORONARY ARTERY REPERFUSIONUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2000NATIONAL HEART
$375,717
7P01HL059139-04MYCARDIAL HYPERTOPHY AND HEART FAILUREUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2000NATIONAL HEART
$1,746,064
5P01HL069020-10-6Molecular Mechanisms in Chronically Stunned MyocardiumUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$342,976
5P01AG027211-04Longevity and Stress ResistanceUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL INSTITUTE ON AGING
$2,054,477
1R01HL102472-01Intrinsic Vascular Smooth Muscle Cell StiffnessUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$491,296
1P20HL101420-01AC5 Inhibitor Treatment for Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$779,111
5P01HL059139-08Myocardial Hypertrophy and Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2005NATIONAL HEART
$1,971,977
5P01HL069020-05-0002Mechanisms underlying short term, chronic and true hiberUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2005NATIONAL HEART
$322,754
5R01HL033107-22Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2005NATIONAL HEART
$665,935
5T32HL069752-02Integrative Mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2005NATIONAL HEART
$458,703
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 7R37HL033107-17
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Cardiovascular control in normal and disease states
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 7R37HL033107-17
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Title Abstract Authors Year Rel
Peripheral vascular endothelial dysfunction and apoptosis in old monkeys. Arteriosclerosis, thrombosis, and vascular biology.. 2000 Jun 20 (6) :1493-9 Asai, K; Kudej, R K; Shen, Y T; Yang, G P; Takagi, G; Kudej, A B; Geng, Y J; Sato, N; Nazareno, J B; Vatner, D E; Natividad, F; Bishop, S P; Vatner, S F 2000
Nitric oxide, an important regulator of perfusion-contraction matching in conscious pigs. American journal of physiology. Heart and circulatory physiology.. 2000 Jul 279 (1) :H451-6 Kudej, R K; Kim, S J; Shen, Y T; Jackson, J B; Kudej, A B; Yang, G P; Bishop, S P; Vatner, S F 2000
beta-adrenergic receptor signaling: an acute compensatory adjustment-inappropriate for the chronic stress of heart failure? Insights from Gsalpha overexpression and other genetically engineered animal models. Circulation research.. 2000 Mar 17 86 (5) :502-6 Vatner, S F; Vatner, D E; Homcy, C J 2000