Defining the human microbiome

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Project Title: Defining the human microbiome
Principal Investigators (PI): BIRREN BRUCE W
Project Number: 5U54HG004969-02
Organization: BROAD INSTITUTE, INC
 
Project Description:
The Human Microbiome consists of all the organisms that comprise the many distinct microbial communities found on and in the human body. Early individual studies and the concerted initial steps of the Human Microbiome Project (HMP) have begun to define the extent of the diversity within these communities and the importance of their structure and temporal variation on human health. To establish the necessary foundation to measure the variation of communities and the functional consequences, we must: i) establish baseline measurements of these communities, including cataloging both the presence and prevalence of specific organisms and their gene content;ii) determine the physiological capabilities of each organism in the community by elaborating their gene content, to be able to interpret the functional significance of changes in community structure;iii) continue to develop new methods to characterize microbial communities and the organisms therein;and, iv) promote research in human metagenomics by engaging the research community and creating publicly available data and resources. We will take advantage of the explosive advances in new sequencing technologies to rapidly create a catalog of over 400 reference microbial genome sequences, including those of bacteria, eukaryotes, and viruses, as well as generate extensive community profiles from a number of human body sites with a focus on the oral and vaginal microbiome. We will also aggressively develop and apply new methods and technologies to further reduce the cost and expand the reach of the HMP. These data will be rapidly released to the public and, along with those of our collaborating partners in the HMP network, will define the Human Microbiome communities and provide baseline measurements for a wealth of subsequent experimental research. Public Health Relevance: The ultimate goal of the HMP is to understand how microbial community structure and function determine normal human health, development, and disease, and can contribute to new diagnostic or therapeutic tools. To do this we must first generate large, public data sets that define the organisms commonly found in healthy human subjects, and measure the extent to which they vary and the reasons for this.
 
Project Terms:
Bacteria Bacteriophages Cataloging Catalogs Communities Complex Data Data Banks Data Bases Data Set Databank, Electronic Databanks Database, Electronic Databases Dataset Deposit Deposition Development Diet Discipline Disease Disorder Drugs Eukaryota Eukaryote Foundations Functional Metagenomics Genes Genetic Genital System, Female, Vagina Genome Goals Health Human Human Figure Human Genome Human Microbiome Human body Human, General Individual Man (Taxonomy) Man, Modern Measurement Measures Medication Metagenomics Methods Microbe Genome Sequencing Microbial Genome Sequencing NIH National Institutes of Health National Institutes of Health (U.S.) Oral Organism Phages Pharmaceutic Preparations Pharmaceutical Preparations Phase Phylogenetic Analysis Phylogenetics Physiologic Physiological Prevalence Production R01 Mechanism R01 Program RNA Viruses RPG Research Research Grants Research Project Grants Research Projects Research Projects, R-Series Research Resources Resources Sampling Shotgun Sequencing Site Specific qualifier value Specified Structure Survey Instrument Surveys Technology Therapeutic Time United States National Institutes of Health Vagina Vaginal Variant Variation Virus Viruses, General Work bacterial virus clinical data repository clinical data warehouse cost data repository disease/disorder drug/agent eukaryotida experiment experimental research experimental study falls flexibility genome sequencing human subject living system meetings member metagenome sequencing metagenomic sequencing microbial community microbiome new diagnostics new technology next generation diagnostics normal aging novel diagnostics public health relevance relational database research study technology development tool
Project Title: Defining the human microbiome
Principal Investigators (PI): BIRREN BRUCE W
Project Number: 5U54HG004969-02
Organization: BROAD INSTITUTE, INC
 
Project Categories:
• Natural Sciences
 
Other Information:
Fiscal Year: 2009
Project Start Date: 30 July 2009
Project End Date: 30 April 2013
Administering Institute Or Center: HG
 
Project Funding Information:
Total Funding: $4,135,549
Year Funding Organization Total Funding, $
2010 NATIONAL HUMAN GENOME RESEARCH INSTITUTE $4,135,549
Project Title: Defining the human microbiome
Principal Investigators (PI): BIRREN BRUCE W
Project Number: 5U54HG004969-02
Organization: BROAD INSTITUTE, INC
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Defining the human microbiome
Principal Investigators (PI): BIRREN BRUCE W
Project Number: 5U54HG004969-02
Organization: BROAD INSTITUTE, INC
 
Project number Project title Organization FY Funding Organization FY Total Cost
272200900018C-3-0-14GENOMIC SEQUENCING CENTERS FOR INFECTIOUS DISEASESBROAD INSTITUTE, INC2010NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
$2,000,000
5U54HG004969-02Defining the Human MicrobiomeBROAD INSTITUTE, INC2010NATIONAL HUMAN GENOME RESEARCH INSTITUTE
$4,135,549
Project Title: Defining the human microbiome
Principal Investigators (PI): BIRREN BRUCE W
Project Number: 5U54HG004969-02
Organization: BROAD INSTITUTE, INC
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Defining the human microbiome
Principal Investigators (PI): BIRREN BRUCE W
Project Number: 5U54HG004969-02
Organization: BROAD INSTITUTE, INC
 
Title Abstract Authors Year Rel