Developmental projects

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Project Title: Developmental projects
Principal Investigators (PI): LAMPE JOHANNA W
Project Number: 5U54CA116847-05-9005
Parent Project: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Project Description:
Consistent with our systematic approach to developing collaborations between researchers and research institutions, the Seattle TREC Developmental Research Program Core will integrate additional investigators into a transdisciplinary team exploring the mechanisms linking energy balance and carcinogenesis using basic cellular and animal models, as well as studies on humans. The primary goal of the developmental research program is to establish collaborations with scientists across the TREC community to develop and implement new research ideas while providing resources for new scientists to focus on these transdisciplinary areas of research. The tools of molecular biology, physical activity and nutrition behavior change, and novel laboratory research on metabolomics and a new serum apoptosis marker are emphasized in the Developmental Research Program Core. The Seattle TREC center proposal is a transdisciplinary research program that involves clinicians, laboratory scientists and public-health scientists from the Fred Hutchinson Cancer Research Center (FHCRC), the University of Washington (UW), and Colorado State University. As described in the Leadership and Administration Core, a transdisciplinary group of senior leaders is available to interact with each other on a variety of substantive committees - one of which is to evaluate developmental research studies and guide decision making on the prospective use of stored specimens or the collection of prospective specimens needed to conduct these studies, in collaboration with the TREC Steering Committee. In recognition of rapidly changing technology and new and novel applications of such technology for research, as well as the need to identify obesity prevention methods with wide public-health applicability, approximately $180,000 - 250,000 will be available each year in the Seattle TREC Center Developmental Research Program Core budget. The Developmental Research Program Core incorporates a system for seeking and evaluating developmental research study applications, a plan for obtaining progress reports for projects to be funded in the future, and presents two projects that will be initiated next year if funding is available, and two additional concepts for consideration for future years.
 
Project Terms:
21+ years old ACRP30 protein Abnormal Assessment of Metabolism Acute-Phase Proteins Address Adolescent Adolescent Youth Adult Affect Animal Model Animal Models and Related Studies Animals Antigenic Determinants Apoptosis Apoptosis Pathway Apoptotic Area Assay Autoregulation Binding Determinants Bioassay Biologic Assays Biological Assay Biopsy Biopsy Sample Biopsy Specimen Blood Plasma Blood Serum Body Tissues Body Weight decreased Budgets C-reactive protein Cancer Causing Agents Cancer Induction Cancer Prevention Intervention Cancer and Nutrition Cancers Carcinogens Case-Base Studies Case-Comparison Studies Case-Compeer Studies Case-Control Studies Case-Referent Studies Case-Referrent Studies Cell Culture Techniques Cell Cycle Cell Death Cell Death, Programmed Cell Division Cycle Cell Growth in Number Cell Multiplication Cell Proliferation Cell/Tissue, Immunohistochemistry Cellular Proliferation Cellular biology Classification Collaborations Collection Colon Colon or Rectum Colorado Colorectal Colorectal Neoplasms Common Rat Strains Communities Complement Complement Proteins Cytokeratin 18 DNA Molecular Biology Data Decision Making Development Diabetes Mellitus, Adult-Onset Diabetes Mellitus, Ketosis-Resistant Diabetes Mellitus, Non-Insulin-Dependent Diabetes Mellitus, Noninsulin Dependent Diabetes Mellitus, Slow-Onset Diabetes Mellitus, Stable Diabetes Mellitus, Type 2 Diabetes Mellitus, Type II Diet Dietary Intervention Disease Disease Progression Disorder Doctor of Philosophy ESI Mass Spectrometry Eating Electrodes Environmental Exposure Epithelial Cells Epitopes Equilibrium Equipment and supply inventories Ethnic group Evaluation Exercise Exercise Physiology Exercise, Physical Fasting Food Intake Foundations Fred Hutchinson Cancer Research Center Funding Future Gene Proteins Generalized Growth Genomics Goals Growth Health Homeostasis Human Human, Adult Human, General Humulin R Hyperinsulinemia Hyperinsulinism IGF-1 IGF-Binding Protein 3 IGF-I IGF-I-SmC IGF1 IGFBP-3 IGFBP3 IHC Immunohistochemistry Immunohistochemistry Staining Method Individual Institution Insulin Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine- Insulin, Regular Insulin-Like Growth Factor 1 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Insulin-Like Somatomedin Peptide I Intervention Intervention Strategies Intervention Trial Inventory Investigation Investigators Knowledge Laboratory Research Laboratory Scientists Large Intestine Neoplasm Large Intestine Tumor Leadership Life Style Lifestyle Link MODY Maintenance Maintenances Malignant Neoplasms Malignant Tumor Mammals, Rats Mammary Tumorigenesis Man (Taxonomy) Man, Modern Maturity-Onset Diabetes Mellitus Mentors Metabolic Metabolic Pathway Metabolic Studies Metabolic syndrome Metabolism Studies Methods Modeling Molecular Biology Molecular Weight Monitor Mucosa Mucosal Tissue Mucous Membrane NIDDM Neoplasm of the Large Bowel Neoplasms Network Analysis Non-Insulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Novolin R Nutrient Nutrition Nutrition Interventions Nutritional Interventions Nutritional Science Obesity Oncogens Outcome Over weight Overweight Participant Pathway Analysis Pathway interactions Patients Ph.D. PhD Phenotype Physical activity Physiological Homeostasis Pilot Projects Plasma Population Pre-Clinical Model Preclinical Models Process Programs (PT) Programs [Publication Type] Progress Reports Protein Gene Products Proteins Proteins, specific or class, C-reactive Proteomics Public Health R01 Mechanism R01 Program RPG Race Racial Group Randomized Controlled Trials Rat Rattus Reactants, Acute-Phase Reporting Reports, Progress Research Research Design Research Grants Research Personnel Research Project Grants Research Projects Research Projects, R-Series Research Resources Research Specimen Research, Laboratory Researchers Resources Reticuloendothelial System, Serum, Plasma Sampling Science of nutrition Scientist Scientists, Laboratory Serum Serum, Plasma Somatomedin C Specimen Spectrometry, Mass, Electrospray Ionization Stocks, Racial Study Type System System, LOINC Axis 4 Systematics T-Cell Receptor-Rearrangement Excision DNA Circles T2D T2DM TREC Technology Testing Tissue Growth Tissue Sample Tissues Training Tumor of the Large Bowel Tumors Tumors, Colorectal Type 2 diabetes Type II diabetes Universities Washington Weight Weight Loss Weight Reduction Work Youth Youth 10-21 adipocyte complement-related protein 30-kDa adipocyte, C1q and collagen domain containing protein adiponectin adiposity adult human (21+) adult onset diabetes anticancer research apM-1 protein apM1 (adipose-specific) protein austin balance balance function base behavior change biomarker body weight loss cancer prevention cancer research cancer risk candidate marker carcinogenesis cell biology colorectal neoplasia complex biological systems corpulence corpulency corpulentia diet and exercise disease/disorder drug development efficacy testing energy balance experiment experimental research experimental study fasted fasts fitness gene product improved intervention effect interventional strategy juvenile juvenile human ketosis resistant diabetes life style intervention lifestyle intervention malignancy maturity onset diabetes measurement of metabolism metabolic abnormality assessment metabolomics metropolitan model organism molecular phenotype necrocytosis neoplasia neoplasm/cancer neoplastic growth new technology novel nutrition obese obese people obese person obese population obesity prevention ontogeny pathway patient population peer pilot study programs prospective protein expression protein protein interaction public health medicine (field) randomized controlled study rectal research study response skills small molecule study design tool tumor wt-loss
Project Title: Developmental projects
Principal Investigators (PI): LAMPE JOHANNA W
Project Number: 5U54CA116847-05-9005
Parent Project: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Project Categories:
• Theories of aging > Biological theories > Telomere Theory
 
Other Information:
Fiscal Year: 2009
Project Start Date: 1 September 2009
Project End Date: 31 August 2010
Administering Institute Or Center: CA
 
Project Funding Information:
Total Funding: $330,765
Year Funding Organization Total Funding, $
2009 NATIONAL CANCER INSTITUTE $330,765
Project Title: Developmental projects
Principal Investigators (PI): LAMPE JOHANNA W
Project Number: 5U54CA116847-05-9005
Parent Project: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Developmental projects
Principal Investigators (PI): LAMPE JOHANNA W
Project Number: 5U54CA116847-05-9005
Parent Project: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Project number Project title Organization FY Funding Organization FY Total Cost
1R03CA107818-01DNA Damage: Fruit &Vegetable Effects in a Feeding TrialFRED HUTCHINSON CANCER RESEARCH CENTER2004NATIONAL CANCER INSTITUTE
$80,435
5R01CA097366-02Breast and Bone Density: Impact of Colonic EnvironmentFRED HUTCHINSON CANCER RESEARCH CENTER2004NATIONAL CANCER INSTITUTE
$449,352
5R01CA092288-04Glucuronidation in Humans--Genotypes and PhenotypesFRED HUTCHINSON CANCER RESEARCH CENTER2004NATIONAL CANCER INSTITUTE
$468,136
5R03CA097475-02Hormone Status Postmenopause: Colonic Bacterial EffectsFRED HUTCHINSON CANCER RESEARCH CENTER2003NATIONAL CANCER INSTITUTE
$80,253
1R01CA097366-01A1Breast and Bone Density: Impact of Colonic EnvironmentFRED HUTCHINSON CANCER RESEARCH CENTER2003NATIONAL CANCER INSTITUTE
$478,075
5R01CA092288-03Glucuronidation in Humans--Genotypes and PhenotypesFRED HUTCHINSON CANCER RESEARCH CENTER2003NATIONAL CANCER INSTITUTE
$708,261
5R01CA070913-05Glutathione Transferases in Humans: Dietary InfluencesFRED HUTCHINSON CANCER RESEARCH CENTER2003NATIONAL CANCER INSTITUTE
$897,184
5U01CA072035-05PHYTOESTROGENS AND COLON EPITHELIUM--A RANDOMIZED TRIALFRED HUTCHINSON CANCER RESEARCH CENTER2001NATIONAL CANCER INSTITUTE
$451,696
1R03CA097475-01Hormone Status Postmenopause: Colonic Bacterial EffectsFRED HUTCHINSON CANCER RESEARCH CENTER2002NATIONAL CANCER INSTITUTE
$80,435
5R03CA092772-02Serum IGFs--Effects of a Soy Intervention in HumansFRED HUTCHINSON CANCER RESEARCH CENTER2002NATIONAL CANCER INSTITUTE
$80,938
5R03CA089785-02HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCEFRED HUTCHINSON CANCER RESEARCH CENTER2002NATIONAL CANCER INSTITUTE
$86,500
5R01CA092288-02Glucuronidation in Humans--Genotypes and PhenotypesFRED HUTCHINSON CANCER RESEARCH CENTER2002NATIONAL CANCER INSTITUTE
$694,433
2R01CA070913-04A2Glutathione Transferases in Humans: Dietary InfluencesFRED HUTCHINSON CANCER RESEARCH CENTER2002NATIONAL CANCER INSTITUTE
$676,732
1R03CA092772-01Serum IGFs--Effects of a Soy Intervention in HumansFRED HUTCHINSON CANCER RESEARCH CENTER2001NATIONAL CANCER INSTITUTE
$81,100
1R03CA089785-01HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCEFRED HUTCHINSON CANCER RESEARCH CENTER2001NATIONAL CANCER INSTITUTE
$86,500
1R01CA092288-01Glucuronidation in Humans--Genotypes and PhenotypesFRED HUTCHINSON CANCER RESEARCH CENTER2001NATIONAL CANCER INSTITUTE
$514,863
5U01CA072035-04PHYTOESTROGENS AND COLON EPITHELIUM--A RANDOMIZED TRIALFRED HUTCHINSON CANCER RESEARCH CENTER2000NATIONAL CANCER INSTITUTE
$853,332
5R01CA070913-07Glutathione Transferases in Humans: Dietary InfluencesFRED HUTCHINSON CANCER RESEARCH CENTER2005NATIONAL CANCER INSTITUTE
$954,513
5R01CA097366-03Breast and Bone Density: Impact of Colonic EnvironmentFRED HUTCHINSON CANCER RESEARCH CENTER2005NATIONAL CANCER INSTITUTE
$498,976
5R03CA107818-02DNA Damage: Fruit &Vegetable Effects in a Feeding TrialFRED HUTCHINSON CANCER RESEARCH CENTER2005NATIONAL CANCER INSTITUTE
$80,253
Project Title: Developmental projects
Principal Investigators (PI): LAMPE JOHANNA W
Project Number: 5U54CA116847-05-9005
Parent Project: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Developmental projects
Principal Investigators (PI): LAMPE JOHANNA W
Project Number: 5U54CA116847-05-9005
Parent Project: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Title Abstract Authors Year Rel