Mechanisms of energy balance and cancer prevention

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Project Title: Mechanisms of energy balance and cancer prevention
Principal Investigators (PI): MCTIERNAN ANNE M
Project Number: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Project Description:
[unreadable] (provided by applicant): [unreadable] We propose in the Seattle TREC Center to elucidate the pathways linking components of energy balance to the cancer process using several different study designs, with the transdisciplinary contributions of scientists from medicine, cell biology, animal models, epidemiology, nutrition, gastroenterology, molecular biology, obesity, endocrinology, obesity, cardiology, immunology, biostatistics, mathematics, exercise physiology, and behavioral science. The overarching theme of the Seattle TREC Center will be determining the mechanisms by which energy balance modifies and influences the process of carcinogenesis across the lifespan in a broad range of settings including cell culture, animal models, small-scale human experimental studies, and population-level experimental work. In Project 1 we will bring together basic research efforts underway in our laboratories in an innovative approach to analyzing the cellular effects of hyperglycemia, hyperinsulinemia, and inflammation on growth, proliferation and survival pathways relevant to oncogenesis. In Project 2 we will determine, in an animal model, the effects of caloric restriction and exercise, alone and in combination, on the carcinogenic response in the mammary gland and on the mechanisms by which changes in energy balance modulate the development of cancer. In Project 3 we will investigate the metabolic and cancer biomarker response to experimental high and low glycemic load diets in lean and obese teenagers and young adults in a crossover clinical trial design. Within a randomized controlled trial in Project 4, we will investigate the effects of dietary weight loss and exercise, alone and together, on biomarkers of inflammation, and DNA damage and repair, and the influences of genetic polymorphisms on these associations. In Project 5 we will test a worksite obesity prevention intervention in a geographic area with large representation of low income and minority individuals on body mass index and markers of insulin resistance and inflammation. Our novel laboratory work will include testing intervention effects on serum proteomics and, in a developmental project, on metabolomics, in order to identify biological signals of dietary, exercise, and adiposity. Our investigators have a wealth of expertise in the components of the energy balance and cancer equation, and will provide important scientific leadership, training, and contributions to the overall TREC program. [unreadable] [unreadable]
 
Project Terms:
There are no related terms in database.
Project Title: Mechanisms of energy balance and cancer prevention
Principal Investigators (PI): MCTIERNAN ANNE M
Project Number: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Project Categories:
• Natural Sciences > Aging Diseases and Pathology > Neurodegenerative diseases > Amyotrophic lateral sclerosis
 
Other Information:
Fiscal Year: 2005
Project Start Date: 23 September 2005
Project End Date: 31 August 2011
Administering Institute Or Center: CA
 
Project Funding Information:
Total Funding: $2,461,328
Year Funding Organization Total Funding, $
2009 NATIONAL CANCER INSTITUTE $2,461,328
Project Title: Mechanisms of energy balance and cancer prevention
Principal Investigators (PI): MCTIERNAN ANNE M
Project Number: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Project number Project title Organization FY Funding Organization FY Total Cost
1R01CA105204-01A1EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMENFRED HUTCHINSON CANCER RESEARCH CENTER2004NATIONAL CANCER INSTITUTE
$701,672
5R01CA077572-05EXERCISE INTERVENTION IN COLORECTAL POLYP PATIENTSFRED HUTCHINSON CANCER RESEARCH CENTER2004NATIONAL CANCER INSTITUTE
$813,977
5R01CA077572-04EXERCISE INTERVENTION IN COLORECTAL POLYP PATIENTSFRED HUTCHINSON CANCER RESEARCH CENTER2003NATIONAL CANCER INSTITUTE
$1,544,911
2P30CA015704-30-9041Core--Prevention centerFRED HUTCHINSON CANCER RESEARCH CENTER2003NATIONAL CANCER INSTITUTE
$127,734
5R01CA077572-03EXERCISE INTERVENTION IN COLORECTAL POLYP PATIENTSFRED HUTCHINSON CANCER RESEARCH CENTER2002NATIONAL CANCER INSTITUTE
$971,277
5R01CA077572-02EXERCISE INTERVENTION IN COLORECTAL POLYP PATIENTSFRED HUTCHINSON CANCER RESEARCH CENTER2001NATIONAL CANCER INSTITUTE
$1,567,797
1R01CA077572-01A1EXERCISE INTERVENTION IN COLORECTAL POLYP PATIENTSFRED HUTCHINSON CANCER RESEARCH CENTER2000NATIONAL CANCER INSTITUTE
$1,265,687
5R01CA069334-04EXERCISE EFFECT ON SEX HORMONES IN POSTMENOPAUSAL WOMENFRED HUTCHINSON CANCER RESEARCH CENTER2000NATIONAL CANCER INSTITUTE
$936,515
5R01CA105204-02EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMENFRED HUTCHINSON CANCER RESEARCH CENTER2005NATIONAL CANCER INSTITUTE
$686,454
1U54CA116847-01Mechanisms of Energy Balance and Cancer PreventionFRED HUTCHINSON CANCER RESEARCH CENTER2005NATIONAL CANCER INSTITUTE
$2,472,758
5R01CA105204-03EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMENFRED HUTCHINSON CANCER RESEARCH CENTER2006NATIONAL CANCER INSTITUTE
$671,321
5U54CA116847-02Mechanisms of Energy Balance and Cancer PreventionFRED HUTCHINSON CANCER RESEARCH CENTER2006NATIONAL CANCER INSTITUTE
$2,506,320
5R01CA105204-04EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMENFRED HUTCHINSON CANCER RESEARCH CENTER2007NATIONAL CANCER INSTITUTE
$650,361
5U54CA116847-03Mechanisms of Energy Balance and Cancer PreventionFRED HUTCHINSON CANCER RESEARCH CENTER2007NATIONAL CANCER INSTITUTE
$2,463,212
5R01CA105204-05EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMENFRED HUTCHINSON CANCER RESEARCH CENTER2008NATIONAL CANCER INSTITUTE
$638,799
5U54CA116847-04Mechanisms of Energy Balance and Cancer PreventionFRED HUTCHINSON CANCER RESEARCH CENTER2008NATIONAL CANCER INSTITUTE
$2,478,429
5U54CA116847-04-9001Leadership and Administration CoreFRED HUTCHINSON CANCER RESEARCH CENTER2008NATIONAL CANCER INSTITUTE
$135,328
5R21CA131676-02Effect of exercise and weight loss on adipose tissue biologyFRED HUTCHINSON CANCER RESEARCH CENTER2009NATIONAL CANCER INSTITUTE
$237,600
5U54CA116847-05Mechanisms of Energy Balance and Cancer PreventionFRED HUTCHINSON CANCER RESEARCH CENTER2009NATIONAL CANCER INSTITUTE
$2,461,328
5U54CA116847-05-9001Leadership and Administration CoreFRED HUTCHINSON CANCER RESEARCH CENTER2009NATIONAL CANCER INSTITUTE
$196,241
Project Title: Mechanisms of energy balance and cancer prevention
Principal Investigators (PI): MCTIERNAN ANNE M
Project Number: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Mechanisms of energy balance and cancer prevention
Principal Investigators (PI): MCTIERNAN ANNE M
Project Number: 5U54CA116847-05
Organization: FRED HUTCHINSON CANCER RESEARCH CENTER
 
Title Abstract Authors Year Rel
Candidate mechanisms accounting for effects of physical activity on breast carcinogenesis. IUBMB life. 2009 Sep 61 (9) :895-901 Thompson, Henry J; Jiang, Weiqin; Zhu, Zongjian 2009
Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration. Diabetologia. 2009 May 52 (5) :921-31 Sweet, I R; Gilbert, M; Maloney, E; Hockenbery, D M; Schwartz, M W; Kim, F 2009
A yearlong exercise intervention decreases CRP among obese postmenopausal women. Medicine and science in sports and exercise. 2009 Aug 41 (8) :1533-9 Campbell, Peter T; Campbell, Kristin L; Wener, Mark H; Wood, Brent L; Potter, John D; McTiernan, Anne; Ulrich, Cornelia M 2009
Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation. Arteriosclerosis, thrombosis, and vascular biology. 2009 Sep 29 (9) :1370-5 Maloney, Ezekiel; Sweet, Ian R; Hockenbery, David M; Pham, Matilda; Rizzo, Norma O; Tateya, Sanshiro; Handa, Priya; Schwartz, Michael W; Kim, Francis 2009
The use of pre-hospital mild hypothermia after resuscitation from out-of-hospital cardiac arrest. Journal of neurotrauma. 2009 Mar 26 (3) :359-63 Kim, Francis; Olsufka, Michele; Nichol, Graham; Copass, Michael K; Cobb, Leonard A 2009
Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors. Gut. 2009 May 58 (5) :661-7 Campbell, P T; Curtin, K; Ulrich, C M; Samowitz, W S; Bigler, J; Velicer, C M; Caan, B; Potter, J D; Slattery, M L 2009
A pilot study of sampling subcutaneous adipose tissue to examine biomarkers of cancer risk. Cancer prevention research (Philadelphia, Pa.). 2009 Jan 2 (1) :37-42 Campbell, Kristin L; Makar, Karen W; Kratz, Mario; Foster-Schubert, Karen E; McTiernan, Anne; Ulrich, Cornelia M 2009
Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009 Jul 20 27 (21) :3437-44 Pierce, Brandon L; Ballard-Barbash, Rachel; Bernstein, Leslie; Baumgartner, Richard N; Neuhouser, Marian L; Wener, Mark H; Baumgartner, Kathy B; Gilliland, Frank D; Sorensen, Bess E; McTiernan, Anne; Ulrich, Cornelia M 2009
Correlates of circulating C-reactive protein and serum amyloid A concentrations in breast cancer survivors. Breast cancer research and treatment. 2009 Mar 114 (1) :155-67 Pierce, Brandon L; Neuhouser, Marian L; Wener, Mark H; Bernstein, Leslie; Baumgartner, Richard N; Ballard-Barbash, Rachel; Gilliland, Frank D; Baumgartner, Kathy B; Sorensen, Bess; McTiernan, Anne; Ulrich, Cornelia M 2009
Energetics and mammary carcinogenesis: effects of moderate-intensity running and energy intake on cellular processes and molecular mechanisms in rats. Journal of applied physiology (Bethesda, Md. : 1985). 2009 Mar 106 (3) :911-8 Zhu, Zongjian; Jiang, Weiqin; McGinley, John N; Thompson, Henry J 2009