Statistics center for pediatric type 2 diabetes therapy

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Project Title: Statistics center for pediatric type 2 diabetes therapy
Principal Investigators (PI): HIRST KATHRYN
Project Number: 5U01DK061230-07
Organization: GEORGE WASHINGTON UNIVERSITY
 
Project Description:
The George Washington University Biostatistics Center proposes to serve as the Coordinating Center (CC) for the consortium of investigators being assembled by the NIDDK to conduct clinical trials of type 2 diabetes in children and adolescents. The consortium?s objective is to develop and apply standardized methods, procedures, and measures to the conduct of (1) one multi-center, multi-arm clinical trial of treatment and (2) one or more primary prevention trials. Researchers and investigators from 6-10 clinical centers, the NIDDK, and the CC will comprise the consortium and collaborate under a cooperative agreement mechanism. This consortium will address the concern of health care researchers and providers over the steady and pernicious increase in detection of type 2 diabetes in youth both here and abroad. Knowing the consequences of type 2 diabetes in adults for micro-and macro-vascular disease progression, and knowing the role of adequate treatment and management, medical science seeks to broaden the scope of research to include treatment and prevention in this under-investigated and growing population of patients. The Steering Committee, composed of the Principal Investigators from the CC and each clinical center and the NIDDK project officer, will design and develop each of the clinical trials. The CC will provide centralized support and biostatistical consultation in: the development of protocols, manuals of procedures, data collection forms, and randomization procedures; implementation of a data management system including data quality assessment; interim analysis of protocol performance, patient safety, and treatment efficacy; and final analysis for publication of results in collaboration with the clinical investigators. The CC will establish a secure encrypted and password protected web site for study staff to enhance development, distribution, and use of study documents. We have assembled a team of coordinating center staff and consultants with established credentials and experience in major diabetes research efforts, including the Diabetes Control and Complications Trial and the Diabetes Prevention Program.
 
Project Terms:
(S)-2-ethoxy-4-(2-((3-methyl-1-(2-(1-piperidinyl)-phenyl)butyl)amino)-2-oxoethyl)-benzoic acid 0-11 years old 21+ years old 5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione Abnormal Assessment of Metabolism Accident and Emergency department Address Adolescent Adolescent Youth Adult Advisory Committees Affect African American Afro American Afroamerican American Amniocentesis Analysis, Data Angioplasty Angioplasty, Balloon Angioplasty, Transluminal Appendix Aquadiol Arm Asians Aspiration, Respiratory Atrophic Arthritis Balloon Angioplasty Belief Besnier-Boeck Disease Biometrics Biometry Biometry and Biostatistics Biostatistics Black Populations Black or African American Body Composition Boeck's Sarcoid Breathing Bypass Care, Health Caring Case-Base Studies Case-Comparison Studies Case-Compeer Studies Case-Control Studies Case-Referent Studies Case-Referrent Studies Child Child Youth Childhood Children (0-21) Church Clinic Clinical Clinical Investigator Clinical Research Clinical Study Clinical Treatment Clinical Trials Clinical Trials Data Monitoring Committees Clinical Trials, Unspecified Closure Collaborations Computers Condition Conduct Clinical Trials Consultations Cooperative Agreements Cooperative Agreements, U-Series Coronary County Credentialing Curriculum Data Data Analyses Data Banks Data Bases Data Collection Data Coordinating Center Data Coordination Center Data Monitoring Committees Data Quality Data and Safety Monitoring Boards Databank, Electronic Databanks Database, Electronic Databases Dedications Detection Development Diabetes Mellitus Diabetes Mellitus, Adult-Onset Diabetes Mellitus, Brittle Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus, Juvenile-Onset Diabetes Mellitus, Ketosis-Prone Diabetes Mellitus, Ketosis-Resistant Diabetes Mellitus, Non-Insulin-Dependent Diabetes Mellitus, Noninsulin Dependent Diabetes Mellitus, Slow-Onset Diabetes Mellitus, Stable Diabetes Mellitus, Sudden-Onset Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Type I Diabetes Mellitus, Type II Diagnosis Diagnosis, Antenatal Dietary Fats Dietary Fiber Dilatation, Transluminal Arterial Dimenformon Dimethylbiguanidine Dimethylguanylguanidine Diogyn Diogynets Discipline of obstetrics Disease Disease Progression Disorder Doctor of Philosophy Dropout Drug Kinetics Drugs Education for Intervention Educational Curriculum Educational Intervention Emergency Department Emergency room Endocrine Endocrinology Enrollment Ensure Environmental Factor Environmental Risk Factor Epidemiologic Research Epidemiologic Studies Epidemiological Studies Epidemiology Research Estra-1,3,5(10)-triene-3,17-diol (17beta)- Estrace Estradiol Estradiol-17 beta Estradiol-17beta Estraldine Estrogenic Agents Estrogenic Compounds Estrogens Family member Female Health Foundations Funding Genetic analyses Grant HOSP Head Health Health Educators Health Instruction Health Training Health Tutoring Health education Health system Healthcare Hispanic Populations Hispanics Hispanics or Latinos Hormonal Change Hospitalization Human, Adult Human, Child Humulin R IDD IDDM Imidodicarbonimidic diamide, N,N-dimethyl- Inflammatory Arthritis Infrastructure Infusion Infusion Pumps Infusion procedures Infusors Inhalation Inhaling Inspiration, Respiratory Instruction Intervention Insulin Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine- Insulin Resistance Insulin, Regular Insulin-Dependent Diabetes Mellitus Intake Internal Medicine Internet Intervention Intervention Strategies Intrauterine Diagnosis Investigation Investigators Job Environment Job Location Job Place Job Setting Job Site Journals Knowledge Latino Population Lead Lesion MODY Magazine Manuals Manuscripts Maturity-Onset Diabetes Mellitus Measures Medical Medication Medicine Metabolic Metabolic Control Metabolic Studies Metabolism Studies Metabolism and Endocrinology Metformin Methods Methods and Techniques Methods, Other Minority Monitor Monosomy X Morgagni-Turner syndrome Morgagni-Turner-Albright syndrome Multi-Institutional Clinical Trial Multi-center clinical study Multi-center clinical trial Multi-site clinical study Multi-site clinical trial NICHD NIDDK NIDDM NIH National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Digestive Diseases and Kidney Disorders National Institutes of Health National Institutes of Health (U.S.) Native Americans Natural History New England New Jersey Non-Insulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Northeastern United States Novolin R Numbers Nursing Administration Research Nursing Research, Administrative Nutrition Nutritional Science Obesity Obstetrics Operation Operative Procedures Operative Surgical Procedures Osteoporosis prevention Out-Migrations Outcome Ovocyclin Ovocylin PBO PROV Pacific Island Americans Pacific Islander Pacific Islander American Paper Participant Patients Pb element Pediatrics Percutaneous Transluminal Angioplasty Performance Perfusion Pumps Personal Satisfaction Ph.D. PhD Pharmaceutic Preparations Pharmaceutical Preparations Pharmacokinetics Pharmacology Phase Pilot Projects Pioglitazone Placebos Plants Plants, General Population Post-Menopause Post-menopausal Period Postmenopausal Period Postmenopause Predisposition gene Prenatal Diagnosis Prevention Prevention intervention Primary Prevention Principal Investigator Procedures Programs (PT) Programs [Publication Type] Progynon Protocol Protocols documentation Provider Puberty Publications Publishing Pulmonary Embolism Quality, Data R01 Mechanism R01 Program RPG Randomized Recommendation Reporting Research Research Grants Research Infrastructure Research Personnel Research Project Grants Research Projects Research Projects, R-Series Research Resources Researchers Resources Rheumatoid Arthritis Risk Reduction Role Safety Safety Monitoring Boards Sampling Sarcoidosis Schaumann's Disease Science Science of Medicine Science of Statistics Science of nutrition Scientific Publication Screening procedure Secure Series Sham Treatment Shereshevskii-Turner syndrome Siblings Site Spanish Origin Statistics Stents Stimulus Surgical Surgical Interventions Surgical Procedure Susceptibility Gene System System, LOINC Axis 4 T1 diabetes T1D T1DM T2D T2DM Task Forces Techniques Technology Testing Therapeutic Estradiol Therapeutic Estrogen Training Intervention Treatment Efficacy Turner syndrome (TS) Turner's Syndrome Turner-Albright syndrome Type 1 diabetes Type 2 diabetes Type II diabetes U-Series Cooperative Agreements Ullrich-Turner syndrome Ullrich-Turner syndrome (UTS) United States National Institutes of Health Universities Upper arm Vascular Diseases Vascular Disorder Vermiform Appendix Villus Visit WWW Washington Week Woman Women's Health Work Work Location Work Place Work-Site Workplace Worksite Writing XO syndrome Youth Youth 10-21 adiposity adult human (21+) adult onset diabetes antepartum diagnosis base black American blood vessel disorder children chromosome XO syndrome clinical data repository clinical data warehouse clinical investigation corpulence corpulency corpulentia data management data repository design designing diabetes diabetes education diabetes mellitus therapy diabetes prevention program diabetes therapy dietary lipid disease/disorder drug/agent enroll environmental risk experience fetal genetic analysis genital dwarfism glucose meter glucose monitor glycemic control heavy metal Pb heavy metal lead hispanic community human puberty impaired glucose tolerance improved inspiration instructional intervention insulin dependent diabetes insulin resistant interest interventional strategy intraluminal angioplasty juvenile juvenile diabetes juvenile diabetes mellitus juvenile human ketosis prone diabetes ketosis resistant diabetes life style intervention lifestyle intervention lymphogranulomatosis lymphogranulomatosis (benign) maturity onset diabetes member metabolic abnormality assessment monosomy X syndrome multi center clinical study multi center clinical trial multi site clinical study multi site clinical trial nutrition obese obese people obese person obese population older women oriental outreach ovarian dwarfism ovarian short stature syndrome patient safety pediatric pediatric pharmacology pilot study post-menopausal postmenopausal predisposing gene primary ovarian insufficiency professor programs prospective protocol development pseudonuchal infantilism randomisation randomization randomly assigned relational database repaglinide screening screenings sham therapy social role statistics statistics/biometry success surgery therapeutic efficacy therapeutically effective trial regimen trial treatment type 2 diabetes in children type I diabetes volunteer web well-being whole grain work environment work setting world wide web youngster
Project Title: Statistics center for pediatric type 2 diabetes therapy
Principal Investigators (PI): HIRST KATHRYN
Project Number: 5U01DK061230-07
Organization: GEORGE WASHINGTON UNIVERSITY
 
Other Information:
Fiscal Year: 2001
Project Start Date: 30 September 2001
Project End Date: 28 February 2009
Administering Institute Or Center: DK
 
Project Funding Information:
Total Funding: $28,375,332
Year Funding Organization Total Funding, $
2008 NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES $28,375,332
Project Title: Statistics center for pediatric type 2 diabetes therapy
Principal Investigators (PI): HIRST KATHRYN
Project Number: 5U01DK061230-07
Organization: GEORGE WASHINGTON UNIVERSITY
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Statistics center for pediatric type 2 diabetes therapy
Principal Investigators (PI): HIRST KATHRYN
Project Number: 5U01DK061230-07
Organization: GEORGE WASHINGTON UNIVERSITY
 
Project number Project title Organization FY Funding Organization FY Total Cost
5U01DK061230-03Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2004NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$9,273,537
3U01DK061230-03S1Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2004NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$208,171
3U01DK061230-03S2Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2004NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$152,000
5U01DK060817-04Minimally Invasive Surgical Therapies Consortium for BPHGEORGE WASHINGTON UNIVERSITY2004NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$776,070
3U01DK061230-02S1Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2003NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$165,589
5U01DK061230-02Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2003NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$10,020,545
5U01DK060817-03Minimally Invasive Surgical Therapies Consortium for BP*GEORGE WASHINGTON UNIVERSITY2003NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$755,669
1U01DK061230-01Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2001NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$5,500,000
1U01DK060817-01Minimally Invasive Surgical Therapies Consortium/BPHGEORGE WASHINGTON UNIVERSITY2001NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$300,000
3U01DK061230-01S2Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2002NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$12,600,000
3U01DK061230-01S1Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2002NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$487,171
5U01DK060817-02Minimally Invasive Surgical Therapies Consortium for BP*GEORGE WASHINGTON UNIVERSITY2002NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$712,500
3U01DK060817-02S1Minimally Invasive Surgical Therapies Consortium for BP*GEORGE WASHINGTON UNIVERSITY2002NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$450,000
5U01DK061230-04Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2005NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$31,125,393
5U01DK061230-05Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2006NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$20,018,635
3U01DK061230-05S1Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2006NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$750,000
3U01DK061230-06S2Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2007NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$1,169,372
3U01DK061230-06S3Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2007NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$2,000,000
3U01DK061230-06S4Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2007NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$226,343
3U01DK061230-06S1Statistics Center for Pediatric Type 2 Diabetes TherapyGEORGE WASHINGTON UNIVERSITY2007NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$1,490,215
Project Title: Statistics center for pediatric type 2 diabetes therapy
Principal Investigators (PI): HIRST KATHRYN
Project Number: 5U01DK061230-07
Organization: GEORGE WASHINGTON UNIVERSITY
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Statistics center for pediatric type 2 diabetes therapy
Principal Investigators (PI): HIRST KATHRYN
Project Number: 5U01DK061230-07
Organization: GEORGE WASHINGTON UNIVERSITY
 
Title Abstract Authors Year Rel
Impact of portion-size control for school a la carte items: changes in kilocalories and macronutrients purchased by middle school students. Journal of the American Dietetic Association. 2008 Jan 108 (1) :140-4 Hartstein, Jill; Cullen, Karen W; Reynolds, Kim D; Harrell, Joanne; Resnicow, Ken; Kennel, Phyllis; STOPP T2D Prevention Study Group 2008
Prevalence of the metabolic syndrome among a racially/ethnically diverse group of U.S. eighth-grade adolescents and associations with fasting insulin and homeostasis model assessment of insulin resistance levels. Diabetes care. 2008 Oct 31 (10) :2020-5 Studies to Treat or Prevent Pediatric Type 2 Diabetes Prevention Study Group 2008