Randomized trial of 11-14 week amniocentesis and ta cvs

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Project Title: Randomized trial of 11-14 week amniocentesis and ta cvs
Principal Investigators (PI): JACKSON LAIRD G
Project Number: 5R01HD031991-03
Organization: THOMAS JEFFERSON UNIVERSITY
 
Project Description:
DESCRIPTION: This is a revised proposal for a randomized comparison of the safety and accuracy of transabdominal amniocentesis and transabdominal CVS, each done during the same modified gestational age window of 77-104 days post last menstrual period (LMP) in contrast to 105-125 days post LMP for amniocentesis and 63-76 days post LMP for CVS. A consortium of 12 experienced prenatal diagnostic centers has been formed to facilitate patient acquisition and completion of the proposed project in a timely fashion. The group includes as principal investigators researchers with expertise in obstetrics, medical genetics, cytogenetics, pediatrics, epidemiology, biostatistics, and the conduct of cooperative clinical trials. The specific aims for the study are to compare transabdominal amniocentesis and CVS at 77-104 days gestation with respect to: Preterm delivery or fetal loss from cytogenetically normal pregnancies, at less than 28 completed gestational weeks; total fetal loss including neonatal death before discharge; Amniotic fluid loss resulting in a pocket of less than 1 cm; gestational age at delivery; perinatal morbidity: intrauterine growth retardation (IUGR), neonatal respiratory problems and other complications; limb defects and other congenital anomalies of the newborn; failure to obtain a sample for diagnosis; failure to obtain a diagnosis; cytogenetic accuracy for diagnosis of abnormal karyotype (by standard culture methods); the diagnostic accuracy and applicability of fluorescence in situ hybridization (FISH) in CVS and amniotic fluid samples, as compared with standard methods; the accuracy of amniotic fluid alphafetoprotein and acetylcholinesterase at 77-104 days gestation for diagnosis of neural tube defects.
 
Project Terms:
fluorescent in situ hybridization evaluation /testing gestational age chorionic villus sampling embryo /fetus disorder amniocentesis pregnancy genetic disorder diagnosis diagnosis quality /standard diagnosis procedure safety women's health pregnancy loss cytogenetics clinical trials clinical research female human pregnant subject
Project Title: Randomized trial of 11-14 week amniocentesis and ta cvs
Principal Investigators (PI): JACKSON LAIRD G
Project Number: 5R01HD031991-03
Organization: THOMAS JEFFERSON UNIVERSITY
 
Project Categories:
• Natural Sciences > Experimental techniques > in vitro methods > Genomic analys > FISH
 
Other Information:
Fiscal Year: 1996
Project Start Date: 16 September 1996
Project End Date: 30 June 2001
Administering Institute Or Center: NICHD
 
Project Funding Information:
Total Funding: $876,479
Year Funding Organization Total Funding, $
1998 National Institute of Child Health and Human Development $876,479
Project Title: Randomized trial of 11-14 week amniocentesis and ta cvs
Principal Investigators (PI): JACKSON LAIRD G
Project Number: 5R01HD031991-03
Organization: THOMAS JEFFERSON UNIVERSITY
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Randomized trial of 11-14 week amniocentesis and ta cvs
Principal Investigators (PI): JACKSON LAIRD G
Project Number: 5R01HD031991-03
Organization: THOMAS JEFFERSON UNIVERSITY
 
Project number Project title Organization FY Funding Organization FY Total Cost
1R01HD031991-01A1RANDOMIZED TRIAL OF 11-14 WEEK AMNIOCENTESIS AND TA CVSTHOMAS JEFFERSON UNIVERSITY1996National Institute of Child Health and Human Development
$1,506,031
5R01HD031991-02RANDOMIZED TRIAL OF 11-14 WEEK AMNIOCENTESIS AND TA CVSTHOMAS JEFFERSON UNIVERSITY1997National Institute of Child Health and Human Development
$1,312,557
N01HD043201-008PRENATAL DIAGNOSIS TRIALS--FETAL CELLS/MATERNAL BLOODTHOMAS JEFFERSON UNIVERSITY1999National Institute of Child Health and Human Development
$224,444
5R01HD031991-03RANDOMIZED TRIAL OF 11-14 WEEK AMNIOCENTESIS AND TA CVSTHOMAS JEFFERSON UNIVERSITY1998National Institute of Child Health and Human Development
$876,479
Project Title: Randomized trial of 11-14 week amniocentesis and ta cvs
Principal Investigators (PI): JACKSON LAIRD G
Project Number: 5R01HD031991-03
Organization: THOMAS JEFFERSON UNIVERSITY
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Randomized trial of 11-14 week amniocentesis and ta cvs
Principal Investigators (PI): JACKSON LAIRD G
Project Number: 5R01HD031991-03
Organization: THOMAS JEFFERSON UNIVERSITY
 
Title Abstract Authors Year Rel