Center for psycho-oncology research

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Project Description:
Project Title:	Center for psycho-oncology research
Principal Investigators (PI):	ANTONI MICHAEL HOWARD
Project Number:	5P50CA084944-03
Organization:	UNIVERSITY OF MIAMI CORAL GABLES

This application is for a 5-year Center for Psycho-Oncology Research (CPOR) grant to conduct behavioral, psychological, social, and biomedical research on the interrelationships among cognition, emotion, biological processes, and physical health in patients with different forms of cancer including breast cancer, prostate cancer and AIDS-related cervical neoplasia. The Center will systematically evaluate the efficacy group-based Cognitive Behavioral Stress Management (CBSM) intervention in Projects 1, 2 and 3., and a pharmacological hormonal treatment in Project 4, for improving quality of life and physical health in patients with different types of cancer or carcinogenic processes associated with reproductive health or hormonal functioning. These include women with breast cancer, older men with prostate cancer, and women at high risk for cervical cancer due to co-infection with Human Immunodeficiency Virus (HIV+) AND Human Papillomavirus (HPV+). Our prior work has shown that CBSM intervention can improve mood, change cognitions and build coping resources; that it modulates the output of sympathetic nervous system (SNS), Hypothalamic Pituitary Adrenal (HPA), and Hypothalamic Pituitary Gonadal (HPG) hormones; and that it helps normalize immunologic status in different populations. The Center will directly address these issues through four (4) randomized clinical trials as follows. Project 1 will (a) evaluate the effects of CBSM intervention on psychological distress, quality of life and biopsy- determined level of cervical cellular atypia; and (b) examine the putative psycho-biological mediators (psychosocial, endocrine, and immunologic changes) on intervention effects observed. Project 2 will (a) investigate the effects of CBSM intervention and quality of life and disease status (change in CA15-3) antigen levels) in women with early-mid stage breast, and (b) examine the putative psycho-biological mediators of intervention effects observed. Project 3 will (a) investigate the effects of CBSM in combination with Viagra (sildenafil citrate) on quality of life and physical health in older men with prostate cancer, and (b) examine the putative psycho-biological mediators of intervention effects observed. Project 4 will (a) evaluate the effects of estrogen therapy (chronic low-dose oral 17- beta estradiotherapy) on mood and quality of life, and physical health in patients with metastatic prostate cancer, and (b) examine the putative psycho-biological mediators of intervention effects observed. The Center will also support and conduct pilot studies of interventions in men and women with other cancers, and will also develop and test other forms of intervention as well as Spanish translations of CBSM for Spanish- speaking Breast and Prostate cancer patients.

Project Terms:
quality of life psychological aspect of cancer psychosocial rehabilitation psychoneuroimmunology cancer rehabilitation /care

Project Categories:
Project Title:	Center for psycho-oncology research
Principal Investigators (PI):	ANTONI MICHAEL HOWARD
Project Number:	5P50CA084944-03
Organization:	UNIVERSITY OF MIAMI CORAL GABLES

• Natural Sciences > Aging Diseases and Pathology > Immune system disorders and inflammation > Adaptive immunity disfunction

Other Information:
Fiscal Year:	1999
Project Start Date:	30 September 1999
Project End Date:	31 August 2004
Administering Institute Or Center:	CA

Project Funding Information:
Total Funding:	$2,101,822

Year	Funding Organization	Total Funding, $
2001	NATIONAL CANCER INSTITUTE	$2,101,822

Project Title:	Center for psycho-oncology research
Principal Investigators (PI):	ANTONI MICHAEL HOWARD
Project Number:	5P50CA084944-03
Organization:	UNIVERSITY OF MIAMI CORAL GABLES

Project_number	Title	Year	FY Total Cost
There are no results for this project in database.

Project Title:	Center for psycho-oncology research
Principal Investigators (PI):	ANTONI MICHAEL HOWARD
Project Number:	5P50CA084944-03
Organization:	UNIVERSITY OF MIAMI CORAL GABLES

Project number	Project title	Organization	FY	Funding Organization	FY Total Cost
3R01CA064710-09S1	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	2003	NATIONAL CANCER INSTITUTE	$30,102
5R01CA064710-09	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	2003	NATIONAL CANCER INSTITUTE	$393,484
5P50CA084944-05	CENTER FOR PSYCHO-ONCOLOGY RESEARCH	UNIVERSITY OF MIAMI CORAL GABLES	2003	NATIONAL CANCER INSTITUTE	$2,217,094
3R01CA064710-08S1	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	2002	NATIONAL CANCER INSTITUTE	$29,358
5R01CA064710-08	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	2002	NATIONAL CANCER INSTITUTE	$497,845
5P50CA084944-04-0001	CBSM effects on quality of life and cervical neoplasia	UNIVERSITY OF MIAMI CORAL GABLES	2002	NATIONAL CANCER INSTITUTE	$206,819
5P50CA084944-04	CENTER FOR PSYCHO-ONCOLOGY RESEARCH	UNIVERSITY OF MIAMI CORAL GABLES	2002	NATIONAL CANCER INSTITUTE	$2,158,930
3R01CA064710-06S1	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	1998	NATIONAL CANCER INSTITUTE	$20,936
3R01CA064710-06S1	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	1999	NATIONAL CANCER INSTITUTE	$20,936
3R01CA064710-06S1	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	2000	NATIONAL CANCER INSTITUTE	$20,936
3R01CA064710-06S1	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	2001	NATIONAL CANCER INSTITUTE	$12,429
5R01CA064710-07	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	2001	NATIONAL CANCER INSTITUTE	$485,104
3R01CA064710-07S1	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	2001	NATIONAL CANCER INSTITUTE	$28,636
3P50CA084944-03S1-0001	CBSM effects on quality of life and cervical neoplasia	UNIVERSITY OF MIAMI CORAL GABLES	2001	NATIONAL CANCER INSTITUTE	$206,819
3P50CA084944-02S1	CENTER FOR PSYCHO-ONCOLOGY RESEARCH	UNIVERSITY OF MIAMI CORAL GABLES	2001	NATIONAL CANCER INSTITUTE	$30,759
5P50CA084944-03	CENTER FOR PSYCHO-ONCOLOGY RESEARCH	UNIVERSITY OF MIAMI CORAL GABLES	2001	NATIONAL CANCER INSTITUTE	$2,101,822
3P50CA084944-03S1	CENTER FOR PSYCHO-ONCOLOGY RESEARCH	UNIVERSITY OF MIAMI CORAL GABLES	2001	NATIONAL CANCER INSTITUTE	$38,656
5R01CA064710-06	FACILITATING POSITIVE ADAPTATION TO BREAST CANCER	UNIVERSITY OF MIAMI CORAL GABLES	2000	NATIONAL CANCER INSTITUTE	$472,732
5P50CA084944-02-0001	CBSM effects on quality of life and cervical neoplasia	UNIVERSITY OF MIAMI CORAL GABLES	2000	NATIONAL CANCER INSTITUTE	$299,994
5P50CA084944-02	CENTER FOR PSYCHO-ONCOLOGY RESEARCH	UNIVERSITY OF MIAMI CORAL GABLES	2000	NATIONAL CANCER INSTITUTE	$2,046,384

Project Title:	Center for psycho-oncology research
Principal Investigators (PI):	ANTONI MICHAEL HOWARD
Project Number:	5P50CA084944-03
Organization:	UNIVERSITY OF MIAMI CORAL GABLES

Project number	Project title	Principal investigator
There are no any related projects.

Project Title:	Center for psycho-oncology research
Principal Investigators (PI):	ANTONI MICHAEL HOWARD
Project Number:	5P50CA084944-03
Organization:	UNIVERSITY OF MIAMI CORAL GABLES

Title	Abstract	Authors	Year	Rel

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