Spore in lung cancer

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Project Title: Spore in lung cancer
Principal Investigators (PI): BAYLIN STEPHEN B
Project Number: 5P50CA058184-12
Organization: JOHNS HOPKINS UNIVERSITY
 
Project Description:
The Johns Hopkins Lung Cancer SPORE is in its tenth year and continues to have as its goals, the performance of highly translational research to move ideas from the bench to bedside, and vice versa, to provide new means for the prevention of, risk assessment for, early detection of, gauging prognosis of, and therapy for, lung cancers of all types. In these efforts, extensive formal collaboration with other Lung Cancer SPORE'S is often emphasized. The program uses the flexibility of the SPORE funding mechanism to extend projects that continually evolve higher and higher translational potential and curtail those that do not. There is an emphasis on constantly bringing in new concepts and directions in parallel with fully evolving those areas that are headed for ultimate translational verification and even reaching common clinical practice. In terms of research at the highest translational level, including work at the population level, the SPORE is presently emphasizing the second and third projects (a collaborative venture with the Colorado SPORE), which are testing epigenetic molecular markers which appear to have very high promise for the areas of risk assessment, early detection, and gauging of prognosis of lung cancer. The first project, also aimed at predicting lung cancer risk and prognosis, is taking new approaches to develop genetic markers for these purposes. A fourth project is developing new concepts for lung cancer prevention by taking the concepts through pre-clinical models and initial proof of principle studies in high risk individuals. This work is very complementary with participation of the Hopkins SPORE in the consortium chemoprevention trials (Lung Cancer Biomarker Chemoprevention Consortium-LCBCC) with the other Lung Cancer SPORES and with a collaborative trial of Iloprost in collaboration with the Colorado SPORE. The fifth and sixth projects are both aimed at development of novel therapeutic strategies for lung cancer with one exploiting new insights into these diseases derived from study of molecular pathways guiding early lung development and the other exploring inhibition of fatty acid synthesis as a new approach.
 
Project Terms:
neoplasm /cancer chemotherapy neoplasm /cancer diagnosis
Project Title: Spore in lung cancer
Principal Investigators (PI): BAYLIN STEPHEN B
Project Number: 5P50CA058184-12
Organization: JOHNS HOPKINS UNIVERSITY
 
Project Categories:
• Natural Sciences > Aging Diseases and Pathology > Cancer & related diseases > Malignant neoplasms (including in situ) > Lung cancer
 
Other Information:
Fiscal Year: 1992
Project Start Date: 30 September 1992
Project End Date: 31 May 2008
Administering Institute Or Center: CA
 
Project Funding Information:
Total Funding: $2,430,329
Year Funding Organization Total Funding, $
2006 NATIONAL CANCER INSTITUTE $2,430,329
Project Title: Spore in lung cancer
Principal Investigators (PI): BAYLIN STEPHEN B
Project Number: 5P50CA058184-12
Organization: JOHNS HOPKINS UNIVERSITY
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Spore in lung cancer
Principal Investigators (PI): BAYLIN STEPHEN B
Project Number: 5P50CA058184-12
Organization: JOHNS HOPKINS UNIVERSITY
 
Project number Project title Organization FY Funding Organization FY Total Cost
2R01CA043318-19Methylation of the Calcitonin Gene in Human TumorsJOHNS HOPKINS UNIVERSITY2004NATIONAL CANCER INSTITUTE
$449,625
5P50CA058184-10SPORE in Lung CancerJOHNS HOPKINS UNIVERSITY2004NATIONAL CANCER INSTITUTE
$2,491,531
5R01CA043318-18METHYLATION OF THE CALCITONIN GENE IN HUMAN TUMORSJOHNS HOPKINS UNIVERSITY2003NATIONAL CANCER INSTITUTE
$435,948
2P50CA058184-09SPORE in Lung CancerJOHNS HOPKINS UNIVERSITY2003NATIONAL CANCER INSTITUTE
$2,500,000
5R01CA043318-17METHYLATION OF THE CALCITONIN GENE IN HUMAN TUMORSJOHNS HOPKINS UNIVERSITY2002NATIONAL CANCER INSTITUTE
$424,197
3P50CA058184-08S2SPORE IN LUNG CANCERJOHNS HOPKINS UNIVERSITY2002NATIONAL CANCER INSTITUTE
$1,826,707
5R01CA043318-16METHYLATION OF THE CALCITONIN GENE IN HUMAN TUMORSJOHNS HOPKINS UNIVERSITY2001NATIONAL CANCER INSTITUTE
$412,892
3P50CA058184-08S1SPORE IN LUNG CANCERJOHNS HOPKINS UNIVERSITY2001NATIONAL CANCER INSTITUTE
$1,829,926
5R01CA054396-10DNA METHYLTRANSFERASE GENE EXPRESSION IN COLON CANCERJOHNS HOPKINS UNIVERSITY2000NATIONAL CANCER INSTITUTE
$362,833
5R01CA043318-15METHYLATION OF THE CALCITONIN GENE IN HUMAN TUMORSJOHNS HOPKINS UNIVERSITY2000NATIONAL CANCER INSTITUTE
$402,935
5P50CA058184-08-0011LUNG CANCER--CAREER DEVELOPMENTJOHNS HOPKINS UNIVERSITY2000NATIONAL CANCER INSTITUTE
$131,614
5P50CA058184-08-0002DNA METHYLATION/NEUROENDOCRINE DIFFERENTIATION--MARKING EARLY STATE LUNG CANCERJOHNS HOPKINS UNIVERSITY2000NATIONAL CANCER INSTITUTE
$131,614
5P50CA058184-08-0010LUNG CANCER--DEVELOPMENTAL RESEARCH PROGRAMJOHNS HOPKINS UNIVERSITY2000NATIONAL CANCER INSTITUTE
$131,614
5P50CA058184-08SPORE IN LUNG CANCERJOHNS HOPKINS UNIVERSITY2000NATIONAL CANCER INSTITUTE
$1,776,628
5P50CA058184-11SPORE in Lung CancerJOHNS HOPKINS UNIVERSITY2005NATIONAL CANCER INSTITUTE
$2,490,165
5R01CA043318-20Methylation of the Calcitonin Gene in Human TumorsJOHNS HOPKINS UNIVERSITY2005NATIONAL CANCER INSTITUTE
$449,625
1R01CA116160-01Developmental pathways, cancer, and DNA hypermethylationJOHNS HOPKINS UNIVERSITY2005NATIONAL CANCER INSTITUTE
$321,678
2P30CA006973-44-0002PROGRAM LEADERSHIPJOHNS HOPKINS UNIVERSITY2006NATIONAL CANCER INSTITUTE
$285,854
2P30CA006973-44-9035MICROARRAYJOHNS HOPKINS UNIVERSITY2006NATIONAL CANCER INSTITUTE
$95,328
2P30CA006973-44-9047CRCJOHNS HOPKINS UNIVERSITY2006NATIONAL CANCER INSTITUTE
$48,571
Project Title: Spore in lung cancer
Principal Investigators (PI): BAYLIN STEPHEN B
Project Number: 5P50CA058184-12
Organization: JOHNS HOPKINS UNIVERSITY
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Spore in lung cancer
Principal Investigators (PI): BAYLIN STEPHEN B
Project Number: 5P50CA058184-12
Organization: JOHNS HOPKINS UNIVERSITY
 
Title Abstract Authors Year Rel
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS medicine. 2006 Oct 3 (10) :e420 Singh, Anju; Misra, Vikas; Thimmulappa, Rajesh K; Lee, Hannah; Ames, Stephen; Hoque, Mohammad O; Herman, James G; Baylin, Stephen B; Sidransky, David; Gabrielson, Edward; Brock, Malcolm V; Biswal, Shyam 2006
Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Archives of biochemistry and biophysics. 2006 Oct 1 454 (1) :7-15 Osburn, William O; Wakabayashi, Nobunao; Misra, Vikas; Nilles, Tricia; Biswal, Shyam; Trush, Michael A; Kensler, Thomas W 2006
Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. Cancer research. 2006 Jun 15 66 (12) :6210-8 Machida, Emi Ota; Brock, Malcolm V; Hooker, Craig M; Nakayama, Jun; Ishida, Akiko; Amano, Jun; Picchi, Maria A; Belinsky, Steven A; Herman, James G; Taniguchi, Shun'ichiro; Baylin, Stephen B 2006
Elevated incidence of lung cancer among HIV-infected individuals. Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2006 Mar 20 24 (9) :1383-8 Engels, Eric A; Brock, Malcolm V; Chen, Jinbo; Hooker, Craig M; Gillison, Maura; Moore, Richard D 2006
Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care. Journal of acquired immune deficiency syndromes (1999). 2006 Sep 43 (1) :47-55 Brock, Malcolm V; Hooker, Craig M; Engels, Eric A; Moore, Richard D; Gillison, Maura L; Alberg, Anthony J; Keruly, Jeanne C; Yang, Stephen C; Heitmiller, Richard F; Baylin, Stephen B; Herman, James G; Brahmer, Julie R 2006
C-fos assessment as a marker of anti-epidermal growth factor receptor effect. Cancer research.. 2006 Feb 15 66 (4) :2385-90 Jimeno, Antonio; Kulesza, Peter; Kincaid, Erik; Bouaroud, Nadia; Chan, Audrey; Forastiere, Arlene; Brahmer, Julie; Clark, Douglas P; Hidalgo, Manuel 2006
LKB1/STK11 suppresses cyclooxygenase-2 induction and cellular invasion through PEA3 in lung cancer. Cancer research. 2006 Aug 15 66 (16) :7870-9 Upadhyay, Sunil; Liu, Chunyan; Chatterjee, Aditi; Hoque, Mohammad O; Kim, Myoung Sook; Engles, James; Westra, William; Trink, Barry; Ratovitski, Edward; Sidransky, David 2006
Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum. BMC genomics. 2006 7 () :308 Acquaah-Mensah, George K; Misra, Vikas; Biswal, Shyam 2006
Overexpression of glycosylphosphatidylinositol (GPI) transamidase subunits phosphatidylinositol glycan class T and/or GPI anchor attachment 1 induces tumorigenesis and contributes to invasion in human breast cancer. Cancer research. 2006 Oct 15 66 (20) :9829-36 Wu, Guojun; Guo, Zhongmin; Chatterjee, Aditi; Huang, Xin; Rubin, Ethel; Wu, Feng; Mambo, Elizabeth; Chang, Xiaofei; Osada, Motonobu; Sook Kim, Myoung; Moon, Chulso; Califano, Joseph A; Ratovitski, Edward A; Gollin, Susanne M; Sukumar, Saraswati; Sidransky, David; Trink, Barry 2006
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. American journal of respiratory cell and molecular biology. 2006 Dec 35 (6) :639-50 Singh, Anju; Rangasamy, Tirumalai; Thimmulappa, Rajesh K; Lee, Hannah; Osburn, William O; Brigelius-Flohe, Regina; Kensler, Thomas W; Yamamoto, Masayuki; Biswal, Shyam 2006
Nested multigene MSP/DHPLC method for analyzing promoter hypermethylation status in clinical samples. BioTechniques. 2006 Jan 40 (1) :40, 42, 44 passim Divine, Kevin K; Liechty, Kieu C; Crume, Kevin C; Belinsky, Steven A 2006
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. The Journal of clinical investigation. 2006 Apr 116 (4) :984-95 Thimmulappa, Rajesh K; Lee, Hannah; Rangasamy, Tirumalai; Reddy, Sekhar P; Yamamoto, Masayuki; Kensler, Thomas W; Biswal, Shyam 2006
Role of lung maintenance program in the heterogeneity of lung destruction in emphysema. Proceedings of the American Thoracic Society. 2006 Nov 3 (8) :673-9 Tuder, Rubin M; Yoshida, Toshinori; Fijalkowka, Iwona; Biswal, Shyam; Petrache, Irina 2006
Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer research.. 2006 Mar 15 66 (6) :3338-44 Belinsky, Steven A; Liechty, Kieu C; Gentry, Frederick D; Wolf, Holly J; Rogers, Justin; Vu, Kieu; Haney, Jerry; Kennedy, Tim C; Hirsch, Fred R; Miller, York; Franklin, Wilbur A; Herman, James G; Baylin, Stephen B; Bunn, Paul A; Byers, Tim 2006
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochemical and biophysical research communications. 2006 Dec 29 351 (4) :883-9 Thimmulappa, Rajesh K; Scollick, Catherine; Traore, Kassim; Yates, Melinda; Trush, Michael A; Liby, Karen T; Sporn, Michael B; Yamamoto, Masayuki; Kensler, Thomas W; Biswal, Shyam 2006