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| Project Title: | Spore in lung cancer | |
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
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| Project Number: | 5P50CA058184-10 | |
| Organization: | JOHNS HOPKINS UNIVERSITY | |
| Project Description: | ||
|---|---|---|
| The Johns Hopkins Lung Cancer SPORE is in its tenth year and continues to have as its goals, the performance of highly translational research to move ideas from the bench to bedside, and vice versa, to provide new means for the prevention of, risk assessment for, early detection of, gauging prognosis of, and therapy for, lung cancers of all types. In these efforts, extensive formal collaboration with other Lung Cancer SPORE'S is often emphasized. The program uses the flexibility of the SPORE funding mechanism to extend projects that continually evolve higher and higher translational potential and curtail those that do not. There is an emphasis on constantly bringing in new concepts and directions in parallel with fully evolving those areas that are headed for ultimate translational verification and even reaching common clinical practice. In terms of research at the highest translational level, including work at the population level, the SPORE is presently emphasizing the second and third projects (a collaborative venture with the Colorado SPORE), which are testing epigenetic molecular markers which appear to have very high promise for the areas of risk assessment, early detection, and gauging of prognosis of lung cancer. The first project, also aimed at predicting lung cancer risk and prognosis, is taking new approaches to develop genetic markers for these purposes. A fourth project is developing new concepts for lung cancer prevention by taking the concepts through pre-clinical models and initial proof of principle studies in high risk individuals. This work is very complementary with participation of the Hopkins SPORE in the consortium chemoprevention trials (Lung Cancer Biomarker Chemoprevention Consortium-LCBCC) with the other Lung Cancer SPORES and with a collaborative trial of Iloprost in collaboration with the Colorado SPORE. The fifth and sixth projects are both aimed at development of novel therapeutic strategies for lung cancer with one exploiting new insights into these diseases derived from study of molecular pathways guiding early lung development and the other exploring inhibition of fatty acid synthesis as a new approach. | ||
| Project Terms: | ||
| clinical research neoplasm /cancer chemotherapy cancer prevention lung neoplasms neoplasm /cancer diagnosis molecular oncology | ||
| Project Title: | Spore in lung cancer | |
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
|
| Project Number: | 5P50CA058184-10 | |
| Organization: | JOHNS HOPKINS UNIVERSITY | |
| Project Categories: | ||
|---|---|---|
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• Natural Sciences > Aging Diseases and Pathology > Cancer & related diseases > Malignant neoplasms (including in situ) > Lung cancer |
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| Other Information: | ||
| Fiscal Year: | 1992 | |
| Project Start Date: | 30 September 1992 | |
| Project End Date: | 31 May 2008 | Administering Institute Or Center: | CA |
| Project Funding Information: | ||
| Total Funding: | $2,491,531 | |
| Year | Funding Organization | Total Funding, $ |
|---|---|---|
| 2004 | NATIONAL CANCER INSTITUTE | $2,491,531 |
| Project Title: | Spore in lung cancer | ||
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
||
| Project Number: | 5P50CA058184-10 | ||
| Organization: | JOHNS HOPKINS UNIVERSITY | ||
| Project_number | Title | Year | FY Total Cost |
|---|---|---|---|
| There are no results for this project in database. | |||
| Project Title: | Spore in lung cancer | ||
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
||
| Project Number: | 5P50CA058184-10 | ||
| Organization: | JOHNS HOPKINS UNIVERSITY | ||
| Project number | Project title | Principal investigator | |
|---|---|---|---|
| There are no any related projects. | |||
| Project Title: | Spore in lung cancer | |||
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
|||
| Project Number: | 5P50CA058184-10 | |||
| Organization: | JOHNS HOPKINS UNIVERSITY | |||
| Title | Abstract | Authors | Year | Rel |
|---|---|---|---|---|
| Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. | The Journal of clinical investigation.. 2004 Nov 114 (9) :1248-59 | Rangasamy, Tirumalai; Cho, Chung Y; Thimmulappa, Rajesh K; Zhen, Lijie; Srisuma, Sorachai S; Kensler, Thomas W; Yamamoto, Masayuki; Petrache, Irina; Tuder, Rubin M; Biswal, Shyam | 2004 |
 
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| An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors. | Cancer research. 2004 Dec 15 64 (24) :9139-43 | Amador, Maria L; Oppenheimer, Darin; Perea, Sofia; Maitra, Anirban; Cusati, George; Iacobuzio-Donahue, Christi; Baker, Sharyn D; Ashfaq, Raheela; Takimoto, Chris; Forastiere, Arlene; Hidalgo, Manuel | 2004 |
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| Chemoprevention of lung cancer--from biology to clinical reality. | Annals of oncology : official journal of the European Society for Medical Oncology / ESMO.. 2004 Feb 15 (2) :185-96 | Winterhalder, R C; Hirsch, F R; Kotantoulas, G K; Franklin, W A; Bunn Jr, P A | 2004 |
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| Promoter hypermethylation of resected bronchial margins: a field defect of changes? | Clinical cancer research : an official journal of the American Association for Cancer Research.. 2004 Aug 1 10 (15) :5131-6 | Guo, Mingzhou; House, Michael G; Hooker, Craig; Han, Yu; Heath, Elizabeth; Gabrielson, Edward; Yang, Stephen C; Baylin, Stephen B; Herman, James G; Brock, Malcolm V | 2004 |
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| Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer. | Oncogene.. 2004 Jan 8 23 (1) :1-8 | Esteller, Manel; Herman, James G | 2004 |
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| Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experience. | The Annals of thoracic surgery.. 2004 Jan 77 (1) :271-7 | Brock, Malcolm V; Kim, Min P; Hooker, Craig M; Alberg, Anthony J; Jordan, Margaret M; Roig, Carmen M; Xu, Li; Yang, Stephen C | 2004 |
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| Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. | Carcinogenesis. 2004 Nov 25 (11) :2053-9 | Balsara, Binaifer R; Pei, Jianming; Mitsuuchi, Yasuhiro; Page, Robert; Klein-Szanto, Andres; Wang, Hao; Unger, Michael; Testa, Joseph R | 2004 |
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| Risk of subsequent primary neoplasms developing in lung cancer patients with prior malignancies. | The Journal of thoracic and cardiovascular surgery.. 2004 Apr 127 (4) :1119-25 | Brock, Malcolm V; Alberg, Anthony J; Hooker, Craig M; Kammer, Anne L; Xu, Li; Roig, Carmen M; Yang, Stephen C | 2004 |
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| Hypermethylation of the GATA genes in lung cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research.. 2004 Dec 1 10 (23) :7917-24 | Guo, Mingzhou; Akiyama, Yoshimitsu; House, Michael G; Hooker, Craig M; Heath, Elizabeth; Gabrielson, Edward; Yang, Stephen C; Han, Yu; Baylin, Stephen B; Herman, James G; Brock, Malcolm V | 2004 |
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| A cross-study comparison of gene expression studies for the molecular classification of lung cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research.. 2004 May 1 10 (9) :2922-7 | Parmigiani, Giovanni; Garrett-Mayer, Elizabeth S; Anbazhagan, Ramaswamy; Gabrielson, Edward | 2004 |
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| A major lung cancer susceptibility locus maps to chromosome 6q23-25. | American journal of human genetics. 2004 Sep 75 (3) :460-74 | Bailey-Wilson, J E; Amos, C I; Pinney, S M; Petersen, G M; de Andrade, M; Wiest, J S; Fain, P; Schwartz, A G; You, M; Franklin, W; Klein, C; Gazdar, A; Rothschild, H; Mandal, D; Coons, T; Slusser, J; Lee, J; Gaba, C; Kupert, E; Perez, A; Zhou, X; Zeng, D; Liu, Q; Zhang, Q; Seminara, D; Minna, J; Anderson, M W | 2004 |
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