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| Project Title: | Myocardial hypertrophy and heart failure | |
| Principal Investigators (PI): |
VATNER STEPHEN F
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| Project Number: | 5P01HL059139-07 | |
| Organization: | UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL | |
| Project Description: | ||
|---|---|---|
| Despite recent advances in the treatment of human heart failure, the overall impact on morbidity and mortality has been limited, and heart failure remains the pre-eminent cardiovascular health problem in the country. Limitations in our understanding can be attributed, in part, to the inability to examine basic mechanisms in appropriate animal models in which the progressive pathogenesis of hypertrophy and heart failure can be studied. Thus, the overall aim of this Program Project is to identify physiological, biochemical and molecular mechanisms which are fundamental to the progression from imposition of the abnormal load to development of compensated hypertrophy to heart failure. A secondary goal is to understand the mechanism of potential therapeutic agents within the context of the pathogenesis of hypertrophy and heart failure, focusing on beta-adreriergic blockade therapy. The latter is central to one of the major themes of this Program Project, i.e., alterations in beta-adrenergic and G-protein signaling in hypertrophy and heart failure. To achieve these goals, we will focus primarily on the study of transgenic mice and a novel canine model of heart failure superimposed on chronic, severe cardiac hypertrophy. The organization of the Program Project includes 4 projects and 3 cores. The first Project will examine genomic and proteomic mechanisms of hypertrophy and heart failure utilizing the novel canine model of severe, chronic cardiac hypertrophy with heart failure superimposed. The next Project will emphasizes altered beta-adrenergic receptor signaling and signaling mechanisms involving stress-activated protein kinases in hypertrophy and heart failure. The overall goals of this projectare to elucidate cellular and molecular mechanisms, which may explain the adverse action of enhanced beta-adrenergic receptor signaling in heart failure and conversely, the salutary action of beta-adrenergic receptor blockade therapy. The next Project is designed to provide novel information on molecular mechanisms of adenylyl Cyclase regulation, also, using transgenic models. The final Project will focuses on molecular mechanisms involving Gprotein coupled receptor signaling, e.g., beta-adrenergic and angiotensin receptors in the development of hypertrophy and heart failure. This Program Project will provide significant new information on molecular mechanisms involved in mediating hypertrophy and heart failure, which will also have relevance for understanding corresponding mechanisms in myocardial ischemic disease as well. | ||
| Project Terms: | ||
| heart function heart failure ventricular hypertrophy pathologic process | ||
| Project Title: | Myocardial hypertrophy and heart failure | |
| Principal Investigators (PI): |
VATNER STEPHEN F
|
|
| Project Number: | 5P01HL059139-07 | |
| Organization: | UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL | |
| Project Categories: | ||
|---|---|---|
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• Natural Sciences > Aging Diseases and Pathology, Aging mechanisms by anatomy > Cardiovascular and cerebrovascular diseases, Tissue level > Heart failure, Differentiated tissues > Muscle tissue |
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| Other Information: | ||
| Fiscal Year: | 1997 | |
| Project Start Date: | 15 September 1997 | |
| Project End Date: | 29 February 2008 | Administering Institute Or Center: | HL |
| Project Funding Information: | ||
| Total Funding: | $1,597,506 | |
| Year | Funding Organization | Total Funding, $ |
|---|---|---|
| 2004 | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | $1,597,506 |
| Project Title: | Myocardial hypertrophy and heart failure | ||
| Principal Investigators (PI): |
VATNER STEPHEN F
|
||
| Project Number: | 5P01HL059139-07 | ||
| Organization: | UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL | ||
| Project_number | Title | Year | FY Total Cost |
|---|---|---|---|
| There are no results for this project in database. | |||
| Project Title: | Myocardial hypertrophy and heart failure | ||
| Principal Investigators (PI): |
VATNER STEPHEN F
|
||
| Project Number: | 5P01HL059139-07 | ||
| Organization: | UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL | ||
| Project number | Project title | Principal investigator | |
|---|---|---|---|
| There are no any related projects. | |||
| Project Title: | Myocardial hypertrophy and heart failure | |||
| Principal Investigators (PI): |
VATNER STEPHEN F
|
|||
| Project Number: | 5P01HL059139-07 | |||
| Organization: | UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL | |||
| Title | Abstract | Authors | Year | Rel |
|---|---|---|---|---|
| Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy. | Circulation research.. 2004 Apr 16 94 (7) :926-35 | Hardt, Stefan E; Tomita, Hideharu; Katus, Hugo A; Sadoshima, Junichi | 2004 |
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| Program of cell survival underlying human and experimental hibernating myocardium. | Circulation research.. 2004 Aug 20 95 (4) :433-40 | Depre, Christophe; Kim, Song-Jung; John, Anna S; Huang, Yanhong; Rimoldi, Ornella E; Pepper, John R; Dreyfus, Gilles D; Gaussin, Vinciane; Pennell, Dudley J; Vatner, Dorothy E; Camici, Paolo G; Vatner, Stephen F | 2004 |
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| Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals. | American journal of physiology. Heart and circulatory physiology.. 2004 Jun 286 (6) :H2219-28 | Yatani, Atsuko; Kim, Song-Jung; Kudej, Raymond K; Wang, Qian; Depre, Christophe; Irie, Keiichi; Kranias, Evangelia G; Vatner, Stephen F; Vatner, Dorothy E | 2004 |
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| Aging increases stiffness of cardiac myocytes measured by atomic force microscopy nanoindentation. | American journal of physiology. Heart and circulatory physiology.. 2004 Aug 287 (2) :H645-51 | Lieber, Samuel C; Aubry, Nadine; Pain, Jayashree; Diaz, Gissela; Kim, Song-Jung; Vatner, Stephen F | 2004 |
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| Computer model of action potential of mouse ventricular myocytes. | American journal of physiology. Heart and circulatory physiology.. 2004 Sep 287 (3) :H1378-403 | Bondarenko, Vladimir E; Szigeti, Gyula P; Bett, Glenna C L; Kim, Song-Jung; Rasmusson, Randall L | 2004 |
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| Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts. | Journal of molecular and cellular cardiology.. 2004 Nov 37 (5) :921-9 | Yan, L; Ge, H; Li, H; Lieber, S C; Natividad, F; Resuello, R R G; Kim, S-J; Akeju, S; Sun, A; Loo, K; Peppas, A P; Rossi, F; Lewandowski, E D; Thomas, A P; Vatner, S F; Vatner, D E | 2004 |
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| Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy. | Journal of molecular and cellular cardiology.. 2004 Aug 37 (2) :477-81 | Matsui, Yutaka; Sadoshima, Junichi | 2004 |
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| Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. | Circulation research.. 2004 Nov 12 95 (10) :971-80 | Alcendor, Ralph R; Kirshenbaum, Lorrie A; Imai, Shin-ichiro; Vatner, Stephen F; Sadoshima, Junichi | 2004 |
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| Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure. | Journal of molecular and cellular cardiology.. 2004 Feb 36 (2) :305-12 | Karoor, Vijaya; Vatner, Stephen F; Takagi, Gen; Yang, Guiping; Thaisz, Jill; Sadoshima, Junichi; Vatner, Dorothy E | 2004 |
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| Negative regulators of cardiac hypertrophy. | Cardiovascular research.. 2004 Aug 15 63 (3) :500-9 | Hardt, Stefan E; Sadoshima, Junichi | 2004 |
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| Limited transfer of cytosolic NADH into mitochondria at high cardiac workload. | American journal of physiology. Heart and circulatory physiology.. 2004 Jun 286 (6) :H2237-42 | O'Donnell, J Michael; Kudej, Raymond K; LaNoue, Kathyrn F; Vatner, Stephen F; Lewandowski, E Douglas | 2004 |
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