General clinical research center

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Project Title: General clinical research center
Principal Investigators (PI): RABKIN MITCHELL T
Project Number: 5M01RR001032-24
Organization: BETH ISRAEL DEACONESS MEDICAL CENTER
 
Project Description:
The Clinical research Center application detailed herein proposes a series of clinical investigations into the etiology, pathophysiology, diagnosis, and treatment of a variety of human disease states. Specific areas of investigation include, among others, the following: The characterization of the differential response to the cysteinyl leukotrienes in patients with bronchial asthma; an examination of the structure of the insulin receptor gene and its relationship to insulin action in vivo and in vitro in patients with different types of diabetes mellitus; an investigation of the role of serotonin in patients with eating disorders; an investigation into the relationship between insulin and the sympathetic nervous system in obesity-related hypertension; the characterization of the mechanisms of impaired thirst and renal sodium excretion in aging; an examination of the efficacy of diet and pharmacotherapy in reversing human coronary atherosclerosis; the early diagnosis and treatment of various prethrombotic states; an investigation of the role of renal amine formation in the pathogenesis of human hypertension; studies of the efficacy of new drugs to treat the complications of AIDS; studies of the mechanism of altered glucose metabolism in aging; studies to determine the efficacy of pharmacotherapy to treat patients with Alzheimers disease and other memory disorders; an investigation to determine whether administration of fish oil mitigates the nephrotoxicity of cyclosporine in renal transplant patients; and an investigation of the optimal mechanisms for achieving successful balloon valvuloplasty of the aortic and mitral valves. The specific research proposals are detailed in this application.
 
Project Terms:
There are no related terms in database.
Project Title: General clinical research center
Principal Investigators (PI): RABKIN MITCHELL T
Project Number: 5M01RR001032-24
Organization: BETH ISRAEL DEACONESS MEDICAL CENTER
 
Project Categories:
• Natural Sciences > Metabolism & Nutrition > Dietary supplements
 
Other Information:
Fiscal Year: 1977
Project Start Date: 1 December 1977
Project End Date: 30 November 1999
Administering Institute Or Center: NCRR
 
Project Funding Information:
Total Funding: $2,832,020
Year Funding Organization Total Funding, $
1999 NATIONAL CENTER FOR RESEARCH RESOURCES $2,832,020
Project Title: General clinical research center
Principal Investigators (PI): RABKIN MITCHELL T
Project Number: 5M01RR001032-24
Organization: BETH ISRAEL DEACONESS MEDICAL CENTER
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: General clinical research center
Principal Investigators (PI): RABKIN MITCHELL T
Project Number: 5M01RR001032-24
Organization: BETH ISRAEL DEACONESS MEDICAL CENTER
 
Project number Project title Organization FY Funding Organization FY Total Cost
5M01RR001032-17GENERAL CLINICAL RESEARCH CENTERBETH ISRAEL DEACONESS MEDICAL CENTER1992NATIONAL CENTER FOR RESEARCH RESOURCES
$1,717,476
3M01RR001032-17S1GENERAL CLINICAL RESEARCH CENTERBETH ISRAEL DEACONESS MEDICAL CENTER1992NATIONAL CENTER FOR RESEARCH RESOURCES
$61,525
5T32DK007516-08INTEGRATED ENDOCRINE AND METABOLIC RESEARCH TRAININGBETH ISRAEL DEACONESS MEDICAL CENTER1992NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$93,294
5M01RR001032-18GENERAL CLINICAL RESEARCH CENTERBETH ISRAEL DEACONESS MEDICAL CENTER1993NATIONAL CENTER FOR RESEARCH RESOURCES
$1,708,419
5T32DK007516-09INTEGRATED ENDOCRINE & METABOLIC RESEARCH TRAININGBETH ISRAEL DEACONESS MEDICAL CENTER1993NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$90,133
5M01RR001032-19GENERAL CLINICAL RESEARCH CENTERBETH ISRAEL DEACONESS MEDICAL CENTER1994NATIONAL CENTER FOR RESEARCH RESOURCES
$1,871,938
5T32DK007516-10INTEGRATED ENDOCRINE & METABOLIC RESEARCH TRAININGBETH ISRAEL DEACONESS MEDICAL CENTER1994NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$104,932
2M01RR001032-20GENERAL CLINICAL RESEARCH CENTERBETH ISRAEL DEACONESS MEDICAL CENTER1995NATIONAL CENTER FOR RESEARCH RESOURCES
$1,924,638
3M01RR001032-21S1GCRC-CAPBETH ISRAEL DEACONESS MEDICAL CENTER1996NATIONAL CENTER FOR RESEARCH RESOURCES
$29,375
3M01RR001032-22S1GCRC CAP DR LAHAMBETH ISRAEL DEACONESS MEDICAL CENTER1997NATIONAL CENTER FOR RESEARCH RESOURCES
$28,750
3M01RR001032-22S2GCRC-CAP-DR MANTZOROSBETH ISRAEL DEACONESS MEDICAL CENTER1997NATIONAL CENTER FOR RESEARCH RESOURCES
$28,750
5M01RR001032-24GENERAL CLINICAL RESEARCH CENTERBETH ISRAEL DEACONESS MEDICAL CENTER1999NATIONAL CENTER FOR RESEARCH RESOURCES
$2,832,020
5M01RR001032-23GENERAL CLINICAL RESEARCH CENTERBETH ISRAEL DEACONESS MEDICAL CENTER1998NATIONAL CENTER FOR RESEARCH RESOURCES
$2,115,355
Project Title: General clinical research center
Principal Investigators (PI): RABKIN MITCHELL T
Project Number: 5M01RR001032-24
Organization: BETH ISRAEL DEACONESS MEDICAL CENTER
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: General clinical research center
Principal Investigators (PI): RABKIN MITCHELL T
Project Number: 5M01RR001032-24
Organization: BETH ISRAEL DEACONESS MEDICAL CENTER
 
Title Abstract Authors Year Rel
Three-dimensional echocardiography improves accuracy and compensates for sonographer inexperience in assessment of left ventricular ejection fraction. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.. 1999 May 12 (5) :290-9 Chuang, M L;Parker, R A;Riley, M F;Reilly, M A;Johnson, R B;Korley, V J;Lerner, A B;Douglas, P S 1999
The effect of thyroid hormone on skeletal integrity. Annals of internal medicine.. 1999 May 4 130 (9) :750-8 Greenspan, S L;Greenspan, F S 1999
Patients with obstructive sleep apnea have an abnormal peripheral vascular response to hypoxia. Journal of applied physiology (Bethesda, Md. : 1985). 1999 Sep 87 (3) :1148-53 Remsburg, S;Launois, S H;Weiss, J W 1999
Subxyphoid access of the normal pericardium: a novel drug delivery technique. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.. 1999 May 47 (1) :109-11 Laham, R J;Simons, M;Hung, D 1999
Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo-controlled trial. Circulation.. 1999 Nov 2 100 (18) :1865-71 Laham, R J;Sellke, F W;Edelman, E R;Pearlman, J D;Ware, J A;Brown, D L;Gold, J P;Simons, M 1999
Intracoronary and intravenous administration of basic fibroblast growth factor: myocardial and tissue distribution. Drug metabolism and disposition: the biological fate of chemicals.. 1999 Jul 27 (7) :821-6 Laham, R J;Rezaee, M;Post, M;Sellke, F W;Braeckman, R A;Hung, D;Simons, M 1999
Forearm bone mineral densitometry cannot be used to monitor response to alendronate therapy in postmenopausal women. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 1999 10 (6) :505-9 Bouxsein, M L;Parker, R A;Greenspan, S L 1999
Classification of osteoporosis and osteopenia in postmenopausal women is dependent on site-specific analysis. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.. 1999 2 (3) :275-83 Varney, L F;Parker, R A;Vincelette, A;Greenspan, S L 1999
Therapeutic myocardial angiogenesis using percutaneous intrapericardial drug delivery. Clinical cardiology.. 1999 Jan 22 (1 Suppl 1) :I6-9 Laham, R J;Hung, D;Simons, M 1999
Risedronate therapy prevents corticosteroid-induced bone loss: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Arthritis and rheumatism.. 1999 Nov 42 (11) :2309-18 Cohen, S;Levy, R M;Keller, M;Boling, E;Emkey, R D;Greenwald, M;Zizic, T M;Wallach, S;Sewell, K L;Lukert, B P;Axelrod, D W;Chines, A A 1999
Oxcarbazepine: double-blind, randomized, placebo-control, monotherapy trial for partial seizures. Neurology.. 1999 Mar 10 52 (4) :732-7 Schachter, S C;Vazquez, B;Fisher, R S;Laxer, K D;Montouris, G D;Combs-Cantrell, D T;Faught, E;Willmore, L J;Morris, G L;Ojemann, L;Bennett, D;Mesenbrink, P;D'Souza, J;Kramer, L 1999
Salivary gland enlargement and elevated serum amylase in bulimia nervosa. Biological psychiatry.. 1999 Jun 1 45 (11) :1520-2 Metzger, E D;Levine, J M;McArdle, C R;Wolfe, B E;Jimerson, D C 1999
Bovine immunoglobulin concentrate-clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine. Gut.. 1999 Feb 44 (2) :212-7 Warny, M;Fatimi, A;Bostwick, E F;Laine, D C;Lebel, F;LaMont, J T;Pothoulakis, C;Kelly, C P 1999
Atrial natriuretic peptide and the development of congestive heart failure in the oldest old: a seven-year prospective study. Journal of the American Geriatrics Society. 1999 Apr 47 (4) :407-11 Knight, E L;Fish, L C;Kiely, D K;Marcantonio, E R;Davis, K M;Minaker, K L 1999
IFN-alpha 2B enhances Th1 cytokine responses in bladder cancer patients receiving Mycobacterium bovis bacillus Calmette-Guerin immunotherapy. Journal of immunology (Baltimore, Md. : 1950). 1999 Feb 15 162 (4) :2399-405 Luo, Y;Chen, X;Downs, T M;DeWolf, W C;O'Donnell, M A 1999
Drug-induced arterial pressure elevation is associated with arousal from NREM sleep in normal volunteers. Journal of applied physiology (Bethesda, Md. : 1985). 1999 Sep 87 (3) :897-901 Kesler, B;Anand, A;Launois, S H;Weiss, J W 1999
Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes. Diabetes.. 1999 May 48 (5) :1192-7 Kennedy, J W;Hirshman, M F;Gervino, E V;Ocel, J V;Forse, R A;Hoenig, S J;Aronson, D;Goodyear, L J;Horton, E S 1999
Changes in renal medullary pO2 during water diuresis as evaluated by blood oxygenation level-dependent magnetic resonance imaging: effects of aging and cyclooxygenase inhibition. Kidney international. 1999 Jan 55 (1) :294-8 Prasad, P V;Epstein, F H 1999