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| Project Title: | General clinical research center | |
| Principal Investigators (PI): |
RABKIN MITCHELL T
|
|
| Project Number: | 5M01RR001032-23 | |
| Organization: | BETH ISRAEL DEACONESS MEDICAL CENTER | |
| Project Description: | ||
|---|---|---|
| The Clinical research Center application detailed herein proposes a series of clinical investigations into the etiology, pathophysiology, diagnosis, and treatment of a variety of human disease states. Specific areas of investigation include, among others, the following: The characterization of the differential response to the cysteinyl leukotrienes in patients with bronchial asthma; an examination of the structure of the insulin receptor gene and its relationship to insulin action in vivo and in vitro in patients with different types of diabetes mellitus; an investigation of the role of serotonin in patients with eating disorders; an investigation into the relationship between insulin and the sympathetic nervous system in obesity-related hypertension; the characterization of the mechanisms of impaired thirst and renal sodium excretion in aging; an examination of the efficacy of diet and pharmacotherapy in reversing human coronary atherosclerosis; the early diagnosis and treatment of various prethrombotic states; an investigation of the role of renal amine formation in the pathogenesis of human hypertension; studies of the efficacy of new drugs to treat the complications of AIDS; studies of the mechanism of altered glucose metabolism in aging; studies to determine the efficacy of pharmacotherapy to treat patients with Alzheimer's disease and other memory disorders; an investigation to determine whether administration of fish oil mitigates the nephrotoxicity of cyclosporine in renal transplant patients; and an investigation of the optimal mechanisms for achieving successful balloon valvuloplasty of the aortic and mitral valves. The specific research proposals are detailed in this application. | ||
| Project Terms: | ||
| clinical research human subject | ||
| Project Title: | General clinical research center | |
| Principal Investigators (PI): |
RABKIN MITCHELL T
|
|
| Project Number: | 5M01RR001032-23 | |
| Organization: | BETH ISRAEL DEACONESS MEDICAL CENTER | |
| Project Categories: | ||
|---|---|---|
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• Natural Sciences > Metabolism & Nutrition > Dietary supplements |
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| Other Information: | ||
| Fiscal Year: | 1977 | |
| Project Start Date: | 1 December 1977 | |
| Project End Date: | 30 November 1999 | Administering Institute Or Center: | NCRR |
| Project Funding Information: | ||
| Total Funding: | $2,115,355 | |
| Year | Funding Organization | Total Funding, $ |
|---|---|---|
| 1998 | NATIONAL CENTER FOR RESEARCH RESOURCES | $2,115,355 |
| Project Title: | General clinical research center | ||
| Principal Investigators (PI): |
RABKIN MITCHELL T
|
||
| Project Number: | 5M01RR001032-23 | ||
| Organization: | BETH ISRAEL DEACONESS MEDICAL CENTER | ||
| Project_number | Title | Year | FY Total Cost |
|---|---|---|---|
| There are no results for this project in database. | |||
| Project Title: | General clinical research center | ||
| Principal Investigators (PI): |
RABKIN MITCHELL T
|
||
| Project Number: | 5M01RR001032-23 | ||
| Organization: | BETH ISRAEL DEACONESS MEDICAL CENTER | ||
| Project number | Project title | Principal investigator | |
|---|---|---|---|
| There are no any related projects. | |||
| Project Title: | General clinical research center | |||
| Principal Investigators (PI): |
RABKIN MITCHELL T
|
|||
| Project Number: | 5M01RR001032-23 | |||
| Organization: | BETH ISRAEL DEACONESS MEDICAL CENTER | |||
| Title | Abstract | Authors | Year | Rel |
|---|---|---|---|---|
| Early changes in biochemical markers of bone turnover predict the long-term response to alendronate therapy in representative elderly women: a randomized clinical trial. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 1998 Sep 13 (9) :1431-8 | Greenspan, S L;Parker, R A;Ferguson, L;Rosen, H N;Maitland-Ramsey, L;Karpf, D B | 1998 |
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| Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results. | The Annals of thoracic surgery.. 1998 Jun 65 (6) :1540-4 | Sellke, F W;Laham, R J;Edelman, E R;Pearlman, J D;Simons, M | 1998 |
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| Randomized trial of pamidronate in patients with thyroid cancer: bone density is not reduced by suppressive doses of thyroxine, but is increased by cyclic intravenous pamidronate. | The Journal of clinical endocrinology and metabolism.. 1998 Jul 83 (7) :2324-30 | Rosen, H N;Moses, A C;Garber, J;Ross, D S;Lee, S L;Ferguson, L;Chen, V;Lee, K;Greenspan, S L | 1998 |
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| Baseline ventilatory function predicts the development of higher levels of fasting insulin and fasting insulin resistance index: the Normative Aging Study. | The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology.. 1998 Sep 12 (3) :641-5 | Lazarus, R;Sparrow, D;Weiss, S T | 1998 |
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| Fall direction, bone mineral density, and function: risk factors for hip fracture in frail nursing home elderly. | The American journal of medicine.. 1998 Jun 104 (6) :539-45 | Greenspan, S L;Myers, E R;Kiel, D P;Parker, R A;Hayes, W C;Resnick, N M | 1998 |
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| Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. | Arthritis and rheumatism.. 1998 Feb 41 (2) :290-7 | Barnett, M L;Kremer, J M;St Clair, E W;Clegg, D O;Furst, D;Weisman, M;Fletcher, M J;Chasan-Taber, S;Finger, E;Morales, A;Le, C H;Trentham, D E | 1998 |
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| Criteria for authorship for statisticians in medical papers. | Statistics in medicine.. 1998 Oct 30 17 (20) :2289-99 | Parker, R A;Berman, N G | 1998 |
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| Minocycline in early diffuse scleroderma. | Lancet.. 1998 Nov 28 352 (9142) :1755-6 | Le, C H;Morales, A;Trentham, D E | 1998 |
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| Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: insight into ischemia-induced reduction in endothelium-dependent vasodilatation. | The Journal of thoracic and cardiovascular surgery.. 1998 Dec 116 (6) :1022-8 | Laham, R J;Simons, M;Tofukuji, M;Hung, D;Sellke, F W | 1998 |
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| The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin. | The Journal of clinical endocrinology and metabolism.. 1998 Aug 83 (8) :2925-32 | Meneilly, G S;Ryan, A S;Minaker, K L;Elahi, D | 1998 |
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| High dose bicalutamide for androgen independent prostate cancer: effect of prior hormonal therapy. | The Journal of urology.. 1998 Jan 159 (1) :149-53 | Joyce, R;Fenton, M A;Rode, P;Constantine, M;Gaynes, L;Kolvenbag, G;DeWolf, W;Balk, S;Taplin, M E;Bubley, G J | 1998 |
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| Impaired ventilatory function and elevated insulin levels in nondiabetic males: the Normative Aging Study. | The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology.. 1998 Sep 12 (3) :635-40 | Lazarus, R;Sparrow, D;Weiss, S T | 1998 |
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| Utility of biochemical markers of bone turnover in the follow-up of patients treated with bisphosphonates. | Calcified tissue international.. 1998 Nov 63 (5) :363-8 | Rosen, H N;Moses, A C;Garber, J;Ross, D S;Lee, S L;Greenspan, S L | 1998 |
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| Temporal relations between obesity and insulin: longitudinal data from the Normative Aging Study. | American journal of epidemiology.. 1998 Jan 15 147 (2) :173-9 | Lazarus, R;Sparrow, D;Weiss, S | 1998 |
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