General clinical research center

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Project Title: General clinical research center
Principal Investigators (PI): TAPLEY DONALD F
Project Number: 5M01RR000645-24
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
 
Project Description:
Continuation of the General Clinical Research Center for adult and pediatric patients at the Columbia-Presbyterian Medical Center in New York City and for adult patients at the St. Lukes/Roosevelt Hospital Center Satellite is proposed for the purpose of providing facilities for multidisciplinary intensive bedside and outpatient clinical investigation of human disease. Support is requested for 1500 "A" days (adult inpatient), 200 "A" days (St. Lukes/Roosevelt), a Core Laboratory, a computer based data management and analysis resource, and a metabolic diet kitchen (nutrition unit). The Center is designed so that acutely ill, as well as ambulatory patients can be studied. The Center provides for hospitalization of patients in a setting in which careful dietary control, skillful intensive nursing care, and precise collection of urine, stool and blood specimens, as well as other special procedures, can be carried out. Qualified faculty members of the clinical and basic science departments of the College of Physicians and Surgeons of Columbia University will study clinical problems which embrace most of the major fields of clinical investigation. Although the primary purpose of the facility is concerned with human research, it also provides unusual opportunities for undergraduate and postgraduate training in clinical investigation. Major research activities include: lipid and lipoprotein metabolism, congestive heart failure, atherosclerosis in children and adults, cardiac arrhythmias, AIDS, Alzheimers disease and other dementias, Parkinsons disease (fetal tissue transplant), stroke, hyperparathyroidism, osteoporosis and other metabolic bone disorders, gene therapy in cancer, ovarian cancer, prostate cancer, mitochondrial encephalomyopathies and mental retardation, obesity, substance abuse/cocaine metabolism, infant nutrition and energy intake, thrombosis, geriatrics/aging, movement disorders, psoriasis, orthopedics, reproductive medicine, attention deficit disorders in children, cardiac denervation and psychophysiological activity, the effects of maternal substance abuse on child development, epidemiology, and obesity and diabetes.
 
Project Terms:
There are no related terms in database.
Project Title: General clinical research center
Principal Investigators (PI): TAPLEY DONALD F
Project Number: 5M01RR000645-24
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
 
Project Categories:
• Natural Sciences > Metabolism & Nutrition > Calcium metabolism
 
Other Information:
Fiscal Year: 1977
Project Start Date: 1 December 1977
Project End Date: 30 June 1996
Administering Institute Or Center: NCRR
 
Project Funding Information:
Total Funding: $2,261,540
Year Funding Organization Total Funding, $
1995 NATIONAL CENTER FOR RESEARCH RESOURCES $2,261,540
Project Title: General clinical research center
Principal Investigators (PI): TAPLEY DONALD F
Project Number: 5M01RR000645-24
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: General clinical research center
Principal Investigators (PI): TAPLEY DONALD F
Project Number: 5M01RR000645-24
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
 
Project number Project title Organization FY Funding Organization FY Total Cost
5M01RR000645-23GENERAL CLINICAL RESEARCH CENTERCOLUMBIA UNIVERSITY HEALTH SCIENCES1994NATIONAL CENTER FOR RESEARCH RESOURCES
$1,715,761
5M01RR000645-24GENERAL CLINICAL RESEARCH CENTERCOLUMBIA UNIVERSITY HEALTH SCIENCES1995NATIONAL CENTER FOR RESEARCH RESOURCES
$2,261,540
3M01RR000645-24S1GCRC-CAP-DR TUCKCOLUMBIA UNIVERSITY HEALTH SCIENCES1995NATIONAL CENTER FOR RESEARCH RESOURCES
$40,034
3M01RR000645-24S2GENERAL CLINICAL RESEARCH CENTERCOLUMBIA UNIVERSITY HEALTH SCIENCES1996NATIONAL CENTER FOR RESEARCH RESOURCES
$1,160,363
3M01RR000645-25S1GENERAL CLINICAL RESEARCH CENTER--MCAPCOLUMBIA UNIVERSITY HEALTH SCIENCES1996NATIONAL CENTER FOR RESEARCH RESOURCES
$40,200
2M01RR000645-25A1GENERAL CLINICAL RESEARCH CENTERCOLUMBIA UNIVERSITY HEALTH SCIENCES1996NATIONAL CENTER FOR RESEARCH RESOURCES
$1,101,619
5M01RR000645-26GENERAL CLINICAL RESEARCH CENTERCOLUMBIA UNIVERSITY HEALTH SCIENCES1997NATIONAL CENTER FOR RESEARCH RESOURCES
$2,558,902
3M01RR000645-28S1GCRCCOLUMBIA UNIVERSITY HEALTH SCIENCES1999NATIONAL CENTER FOR RESEARCH RESOURCES
$54,585
5M01RR000645-28GENERAL CLINICAL RESEARCH CENTERCOLUMBIA UNIVERSITY HEALTH SCIENCES1999NATIONAL CENTER FOR RESEARCH RESOURCES
$3,414,019
3M01RR000645-27S1GCRC CDMAS SUPPLEMENTCOLUMBIA UNIVERSITY HEALTH SCIENCES1998NATIONAL CENTER FOR RESEARCH RESOURCES
$65,427
3M01RR000645-27S2GCRCCOLUMBIA UNIVERSITY HEALTH SCIENCES1998NATIONAL CENTER FOR RESEARCH RESOURCES
$38,712
3M01RR000645-27S3GCRC MCAP OLAKUNLE AKINBOBOYE, MDCOLUMBIA UNIVERSITY HEALTH SCIENCES1998NATIONAL CENTER FOR RESEARCH RESOURCES
$39,314
5M01RR000645-27GENERAL CLINICAL RESEARCH CENTERCOLUMBIA UNIVERSITY HEALTH SCIENCES1998NATIONAL CENTER FOR RESEARCH RESOURCES
$3,058,448
Project Title: General clinical research center
Principal Investigators (PI): TAPLEY DONALD F
Project Number: 5M01RR000645-24
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: General clinical research center
Principal Investigators (PI): TAPLEY DONALD F
Project Number: 5M01RR000645-24
Organization: COLUMBIA UNIVERSITY HEALTH SCIENCES
 
Title Abstract Authors Year Rel
Neuropsychological detection and characterization of preclinical Alzheimer's disease. Neurology.. 1995 May 45 (5) :957-62 Jacobs, D M;Sano, M;Dooneief, G;Marder, K;Bell, K L;Stern, Y 1995
Effect of chronic opioid antagonism on the hypothalamic-pituitary-ovarian axis in hyperprolactinemic women. The Journal of clinical endocrinology and metabolism.. 1995 Feb 80 (2) :540-5 Matera, C;Freda, P U;Ferin, M;Wardlaw, S L 1995
Differential diagnosis in cushing syndrome. Use of corticotropin-releasing hormone. Medicine.. 1995 Mar 74 (2) :74-82 Freda, P U;Wardlaw, S L;Bruce, J N;Post, K D;Goland, R S 1995
Spread of symptoms in idiopathic torsion dystonia. Movement disorders : official journal of the Movement Disorder Society.. 1995 Mar 10 (2) :143-52 Greene, P;Kang, U J;Fahn, S 1995
Increased bone mineral density after parathyroidectomy in primary hyperparathyroidism. The Journal of clinical endocrinology and metabolism. 1995 Mar 80 (3) :729-34 Silverberg, S J;Gartenberg, F;Jacobs, T P;Shane, E;Siris, E;Staron, R B;McMahon, D J;Bilezikian, J P 1995
Risk of human immunodeficiency virus type 1-related neurologic disease in a cohort of intravenous drug users. Archives of neurology.. 1995 Dec 52 (12) :1174-82 Marder, K;Liu, X;Stern, Y;Malouf, R;Dooneief, G;Bell, K;Todak, G;Joseph, M;Sorrell, S;el Sadr, W 1995
Neurologic signs and symptoms in a cohort of homosexual men followed for 4.5 years. Neurology.. 1995 Feb 45 (2) :261-7 Marder, K;Liu, X;Stern, Y;Dooneief, G;Bell, K;Schofield, P;Sacktor, N;Todak, G;Friedman, R;Ehrhardt, A 1995
Cerebral dysfunction after cardiac operations in elderly patients. The Annals of thoracic surgery.. 1995 Dec 60 (6) :1716-22 Heyer, E J;Delphin, E;Adams, D C;Rose, E A;Smith, C R;Todd, C J;Ginsburg, M;Haggerty, R;McMahon, D J 1995
Cerebrospinal fluid homovanillic acid in the DATATOP study on Parkinson's disease. Parkinson Study Group. Archives of neurology.. 1995 Mar 52 (3) :237-45 1995
Clinical correlates of Alzheimer's disease with and without silent radiographic abnormalities. Archives of neurology.. 1995 Feb 52 (2) :146-51 Marder, K;Richards, M;Bello, J;Bell, K;Sano, M;Miller, L;Folstein, M;Albert, M;Stern, Y 1995
APOE genotype influences functional status among elderly without dementia. American journal of medical genetics.. 1995 Dec 18 60 (6) :583-7 Albert, S M;Gurland, B;Maestre, G;Jacobs, D M;Stern, Y;Mayeux, R 1995
The frequency and associated risk factors for dementia in patients with Parkinson's disease. Archives of neurology.. 1995 Jul 52 (7) :695-701 Marder, K;Tang, M X;Cote, L;Stern, Y;Mayeux, R 1995
The age at onset of Alzheimer's disease and an intracranial area measurement. A relationship. Archives of neurology.. 1995 Jan 52 (1) :95-8 Schofield, P W;Mosesson, R E;Stern, Y;Mayeux, R 1995
Effects of single and multiple intravenous cocaine injections in humans maintained on methadone. The Journal of pharmacology and experimental therapeutics.. 1995 Oct 275 (1) :38-47 Foltin, R W;Christiansen, I;Levin, F R;Fischman, M W 1995
Increased risk of mortality in Alzheimer's disease patients with more advanced educational and occupational attainment. Annals of neurology.. 1995 May 37 (5) :590-5 Stern, Y;Tang, M X;Denaro, J;Mayeux, R 1995
Longitudinal measurements of bone density and biochemical indices in untreated primary hyperparathyroidism. The Journal of clinical endocrinology and metabolism. 1995 Mar 80 (3) :723-8 Silverberg, S J;Gartenberg, F;Jacobs, T P;Shane, E;Siris, E;Staron, R B;Bilezikian, J P 1995
Methodological issues in coding sleep states in immature infants. Developmental psychobiology.. 1995 Mar 28 (2) :85-101 Sahni, R;Schulze, K F;Stefanski, M;Myers, M M;Fifer, W P 1995
The effect of pre-eclampsia on human placental corticotrophin-releasing hormone content and processing. Placenta.. 1995 Jun 16 (4) :375-82 Goland, R S;Conwell, I M;Jozak, S 1995
Use of cyclosporin in lupus nephritis. Contributions to nephrology.. 1995 114 () :59-72 Radhakrishnan, J;Valeri, A;Kunis, C;Appel, G B 1995
Preliminary findings from the predictors study: utility of clinical signs for predicting disease course. Alzheimer disease and associated disorders.. 1995 9 Suppl 1 () :S14-8 Stern, Y;Jacobs, D M 1995
RR variability in healthy, middle-aged persons compared with patients with chronic coronary heart disease or recent acute myocardial infarction. Circulation.. 1995 Apr 1 91 (7) :1936-43 Bigger Jr, J T;Fleiss, J L;Steinman, R C;Rolnitzky, L M;Schneider, W J;Stein, P K 1995
Pancreas cancer as a second primary malignancy. A population-based study. Cancer.. 1995 Aug 15 76 (4) :589-92 Neugut, A I;Ahsan, H;Robinson, E 1995
Vagal modulation of RR intervals during head-up tilt and the infusion of isoproterenol. The American journal of cardiology.. 1995 Jun 1 75 (16) :1145-50 Bloomfield, D M;Bigger Jr, J T;Pavri, B B;Han, J;Fleiss, J L;Rolnitzky, L M;Steinman, R C 1995
Factors predictive of the need for levodopa therapy in early, untreated Parkinson's disease. The Parkinson Study Group. Archives of neurology.. 1995 Jun 52 (6) :565-70 McDermott, M P;Jankovic, J;Carter, J;Fahn, S;Gauthier, S;Goetz, C G;Golbe, L I;Koller, W;Lang, A E;Olanow, C W 1995
Differences in the prevalence of essential tremor among elderly African Americans, whites, and Hispanics in northern Manhattan, NY. Archives of neurology.. 1995 Dec 52 (12) :1201-5 Louis, E D;Marder, K;Cote, L;Pullman, S;Ford, B;Wilder, D;Tang, M X;Lantigua, R;Gurland, B;Mayeux, R 1995
Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia. Reproduction, fertility, and development.. 1995 7 (5) :1227-30 Goland, R S;Tropper, P J;Warren, W B;Stark, R I;Jozak, S M;Conwell, I M 1995
Increased early mortality in women undergoing cardiac transplantation. Circulation.. 1995 Feb 15 91 (4) :1029-35 Wechsler, M E;Giardina, E G;Sciacca, R R;Rose, E A;Barr, M L 1995
Double-blind, placebo-controlled study of the long-term efficacy of carvedilol in patients with severe chronic heart failure. Circulation.. 1995 Sep 15 92 (6) :1499-506 Krum, H;Sackner-Bernstein, J D;Goldsmith, R L;Kukin, M L;Schwartz, B;Penn, J;Medina, N;Yushak, M;Horn, E;Katz, S D 1995
Metabolism of meso-2,3-dimercaptosuccinic acid in lead-poisoned children and normal adults. Environmental health perspectives.. 1995 Jul-Aug 103 (7-8) :734-9 Asiedu, P;Moulton, T;Blum, C B;Roldan, E;Lolacono, N J;Graziano, J H 1995
Neuropsychological changes in a prospectively followed cohort of homosexual and bisexual men with and without HIV infection. Neurology.. 1995 Mar 45 (3 Pt 1) :467-72 Stern, Y;Liu, X;Marder, K;Todak, G;Sano, M;Ehrhardt, A;Gorman, J 1995