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| Project Title: | General clinical research center | |
| Principal Investigators (PI): |
DEBAS HAILE T
|
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| Project Number: | 5M01RR000079-36 | |
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | |
| Project Description: | ||
|---|---|---|
| With this renewal, the UCSF General Clinical Research Center begins its 30th year. Our Center is nutritionally focused, supporting a large variety of diet-controlled protocols that result in a high occupancy rate for both inpatient and outpatient studies. Our program is highly diverse by virtue of the variety of nutritional areas supported (carbohydrate, lipid, mineral, acid-base, electrolyte, vitamin D metabolism) and the variety of protocols supported in non-nutritional areas (cardiovascular pharmacology, psychopharmacology, AIDS treatment, allergy, reproductive endocrinology). During the past 5-year grant period, nearly 100 articles resulting from UCSF GCRC studies by 19 different Principal Investigators appeared in print. During the next 5-year period, 17 different Principal Investigators will study: progesterone antagonism of estrogen regulated bone mineral metabolism; circadian rhythms function in elderly; effects of growth hormone and testosterone on vitamin D metabolism in elderly; lipoprotein turnover; psychopharmacology of drug abuse; drug regimens to reverse coronary atherosclerosis; dietary and pharmacological effects on the speciation of high density lipoproteins; effect of prostaglandin inhibition by nonsteroidal anti-inflammatory drugs on bone loss during bed rest in older women; studies of lipoprotein structure in hypo-and hyperlipoproteinemia; diet potassium and hypertension in blacks and elderly; regulation of calcitriol metabolism in health and disease; the effects of aging on calcium blocker kinetics/dynamics; effect of prolonged dietary base supplementation on bone mass in postmenopausal women; effect of age on acid-base homeostasis in normal humans; prophylaxis of Pneumocystis carinii pneumonia in AIDS; dietary cholesterol effects on plasma lipoproteins; postprandial lipid metabolism in coronary artery disease; lipoprotein lipase and hepatic lipase activities in normal and hypertriglyceridemic individuals; neuromediators of allergic rhinopharyngitis; receptor-defective low density lipoproteins; the effect of sulfonylureas on pancreatic beta cell sensitivity; the effect of aging on cardiac R-R variability; noninvasive determination of autonomic regulation of heart rate and AV conduction; effect of anion accompanying diet potassium in treating patients with essential hypertension. By our current projection for the next 5-years, two or more protocols will be devoted to each of the following disorders; hypertension, atherosclerosis, aging, osteoporosis, diabetes mellitus, and AIDS. | ||
| Project Terms: | ||
| clinical research human subject | ||
| Project Title: | General clinical research center | |
| Principal Investigators (PI): |
DEBAS HAILE T
|
|
| Project Number: | 5M01RR000079-36 | |
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | |
| Project Categories: | ||
|---|---|---|
|
• Natural Sciences > Metabolism & Nutrition > Dietology |
||
| Other Information: | ||
| Fiscal Year: | 1974 | |
| Project Start Date: | 1 December 1974 | |
| Project End Date: | 30 November 1999 | Administering Institute Or Center: | NCRR |
| Project Funding Information: | ||
| Total Funding: | $2,316,367 | |
| Year | Funding Organization | Total Funding, $ |
|---|---|---|
| 1998 | NATIONAL CENTER FOR RESEARCH RESOURCES | $2,316,367 |
| Project Title: | General clinical research center | ||
| Principal Investigators (PI): |
DEBAS HAILE T
|
||
| Project Number: | 5M01RR000079-36 | ||
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | ||
| Project_number | Title | Year | FY Total Cost |
|---|---|---|---|
| There are no results for this project in database. | |||
| Project Title: | General clinical research center | ||
| Principal Investigators (PI): |
DEBAS HAILE T
|
||
| Project Number: | 5M01RR000079-36 | ||
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | ||
| Project number | Project title | Principal investigator | |
|---|---|---|---|
| There are no any related projects. | |||
| Project Title: | General clinical research center | |||
| Principal Investigators (PI): |
DEBAS HAILE T
|
|||
| Project Number: | 5M01RR000079-36 | |||
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | |||
| Title | Abstract | Authors | Year | Rel |
|---|---|---|---|---|
| Nutrition, tissue oxygenation, and healing of venous leg ulcers. | Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing.. 1998 Sep 16 (3) :48-56 | Wipke-Tevis, D D;Stotts, N A | 1998 |
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| Phase I study of paclitaxel in patients with recurrent malignant glioma: a North American Brain Tumor Consortium report. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 1998 Jun 16 (6) :2188-94 | Chang, S M;Kuhn, J G;Rizzo, J;Robins, H I;Schold Jr, S C;Spence, A M;Berger, M S;Mehta, M P;Bozik, M E;Pollack, I;Gilbert, M;Fulton, D;Rankin, C;Malec, M;Prados, M D | 1998 |
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| Caffeine demethylation monitoring using a transdermal sweat patch. | Journal of analytical toxicology.. 1998 Nov-Dec 22 (7) :596-600 | Delahunty, T;Schoendorfer, D | 1998 |
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| Pyrazoloacridine for the treatment of hormone-refractory prostate cancer. | Cancer investigation.. 1998 16 (7) :456-61 | Small, E J;Fippin, L J;Whisenant, S P | 1998 |
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| Virologic, immunologic, and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men. | Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.. 1998 Apr 1 17 (4) :314-9 | Palefsky, J M;Holly, E A;Hogeboom, C J;Ralston, M L;DaCosta, M M;Botts, R;Berry, J M;Jay, N;Darragh, T M | 1998 |
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| Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors. | Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.. 1998 Apr 1 17 (4) :320-6 | Palefsky, J M;Holly, E A;Ralston, M L;Arthur, S P;Jay, N;Berry, J M;DaCosta, M M;Botts, R;Darragh, T M | 1998 |
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| Sensitive liquid chromatographic technique to measure isoniazid in alveolar cells, bronchoalveolar lavage and plasma in HIV-infected patients. | Journal of chromatography. B, Biomedical sciences and applications.. 1998 Feb 13 705 (2) :323-9 | Delahunty, T;Lee, B;Conte, J E | 1998 |
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| High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men. | AIDS (London, England). 1998 Mar 26 12 (5) :495-503 | Palefsky, J M;Holly, E A;Ralston, M L;Jay, N;Berry, J M;Darragh, T M | 1998 |
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| Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women. | Journal of clinical pharmacology.. 1998 Dec 38 (12) :1137-43 | Tsunoda, S M;Harris, R Z;Mroczkowski, P J;Benet, L Z | 1998 |
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