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| Project Title: | General clinical research center | |
| Principal Investigators (PI): |
DEBAS HAILE T
|
|
| Project Number: | 5M01RR000079-35 | |
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | |
| Project Description: | ||
|---|---|---|
| With this renewal, the UCSF General Clinical Research Center begins its 30th year. Our Center is nutritionally focused, supporting a large variety of diet-controlled protocols that result in a high occupancy rate for both inpatient and outpatient studies. Our program is highly diverse by virtue of the variety of nutritional areas supported (carbohydrate, lipid, mineral, acid-base, electrolyte, vitamin D metabolism) and the variety of protocols supported in non-nutritional areas (cardiovascular pharmacology, psychopharmacology, AIDS treatment, allergy, reproductive endocrinology). During the past 5-year grant period, nearly 100 articles resulting from UCSF GCRC studies by 19 different Principal Investigators appeared in print. During the next 5-year period, 17 different Principal Investigators will study: progesterone antagonism of estrogen regulated bone mineral metabolism; circadian rhythms function in elderly; effects of growth hormone and testosterone on vitamin D metabolism in elderly; lipoprotein turnover; psychopharmacology of drug abuse; drug regimens to reverse coronary atherosclerosis; dietary and pharmacological effects on the speciation of high density lipoproteins; effect of prostaglandin inhibition by nonsteroidal anti-inflammatory drugs on bone loss during bed rest in older women; studies of lipoprotein structure in hypo-and hyperlipoproteinemia; diet potassium and hypertension in blacks and elderly; regulation of calcitriol metabolism in health and disease; the effects of aging on calcium blocker kinetics/dynamics; effect of prolonged dietary base supplementation on bone mass in postmenopausal women; effect of age on acid-base homeostasis in normal humans; prophylaxis of Pneumocystis carinii pneumonia in AIDS; dietary cholesterol effects on plasma lipoproteins; postprandial lipid metabolism in coronary artery disease; lipoprotein lipase and hepatic lipase activities in normal and hypertriglyceridemic individuals; neuromediators of allergic rhinopharyngitis; receptor-defective low density lipoproteins; the effect of sulfonylureas on pancreatic beta cell sensitivity; the effect of aging on cardiac R-R variability; noninvasive determination of autonomic regulation of heart rate and AV conduction; effect of anion accompanying diet potassium in treating patients with essential hypertension. By our current projection for the next 5-years, two or more protocols will be devoted to each of the following disorders; hypertension, atherosclerosis, aging, osteoporosis, diabetes mellitus, and AIDS. | ||
| Project Terms: | ||
| clinical research human subject | ||
| Project Title: | General clinical research center | |
| Principal Investigators (PI): |
DEBAS HAILE T
|
|
| Project Number: | 5M01RR000079-35 | |
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | |
| Project Categories: | ||
|---|---|---|
|
• Natural Sciences > Metabolism & Nutrition > Dietology |
||
| Other Information: | ||
| Fiscal Year: | 1974 | |
| Project Start Date: | 1 December 1974 | |
| Project End Date: | 30 November 1998 | Administering Institute Or Center: | NCRR |
| Project Funding Information: | ||
| Total Funding: | $2,201,888 | |
| Year | Funding Organization | Total Funding, $ |
|---|---|---|
| 1997 | NATIONAL CENTER FOR RESEARCH RESOURCES | $2,201,888 |
| Project Title: | General clinical research center | ||
| Principal Investigators (PI): |
DEBAS HAILE T
|
||
| Project Number: | 5M01RR000079-35 | ||
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | ||
| Project_number | Title | Year | FY Total Cost |
|---|---|---|---|
| There are no results for this project in database. | |||
| Project Title: | General clinical research center | ||
| Principal Investigators (PI): |
DEBAS HAILE T
|
||
| Project Number: | 5M01RR000079-35 | ||
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | ||
| Project number | Project title | Principal investigator | |
|---|---|---|---|
| There are no any related projects. | |||
| Project Title: | General clinical research center | |||
| Principal Investigators (PI): |
DEBAS HAILE T
|
|||
| Project Number: | 5M01RR000079-35 | |||
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | |||
| Title | Abstract | Authors | Year | Rel |
|---|---|---|---|---|
| Comparison of conventional cytologic smears and ThinPrep preparations from the anal canal. | Acta cytologica.. 1997 Jul-Aug 41 (4) :1167-70 | Darragh, T M; Jay, N; Tupkelewicz, B A; Hogeboom, C J; Holly, E A; Palefsky, J M | 1997 |
 |
| Colposcopic appearance of anal squamous intraepithelial lesions: relationship to histopathology. | Diseases of the colon and rectum.. 1997 Aug 40 (8) :919-28 | Jay, N; Berry, J M; Hogeboom, C J; Holly, E A; Darragh, T M; Palefsky, J M | 1997 |
|
| Anal cytology as a screening tool for anal squamous intraepithelial lesions. | Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.. 1997 Apr 15 14 (5) :415-22 | Palefsky, J M; Holly, E A; Hogeboom, C J; Berry, J M; Jay, N; Darragh, T M | 1997 |
|
| Aging alters calcium regulation of serum concentration of parathyroid hormone in healthy men. | The American journal of physiology.. 1997 Jan 272 (1 Pt 1) :E139-46 | Portale, A A; Lonergan, E T; Tanney, D M; Halloran, B P | 1997 |
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| Genetically determined chloride-sensitive hypertension and stroke. | Proceedings of the National Academy of Sciences of the United States of America.. 1997 Dec 23 94 (26) :14748-52 | Tanaka, M; Schmidlin, O; Yi, S L; Bollen, A W; Morris Jr, R C | 1997 |
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| Reduced dietary potassium reversibly enhances vasopressor response to stress in African Americans. | Hypertension.. 1997 May 29 (5) :1083-90 | Sudhir, K; Forman, A; Yi, S L; Sorof, J; Schmidlin, O; Sebastian, A; Morris Jr, R C | 1997 |
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| Potassium intake and cardiovascular reactivity in children with risk factors for essential hypertension. | The Journal of pediatrics.. 1997 Jul 131 (1 Pt 1) :87-94 | Sorof, J M; Forman, A; Cole, N; Jemerin, J M; Morris, R C | 1997 |
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| High-performance liquid chromatographic determination of pyrazoloacridine, a nitro-9-methoxyacridine anticancer agent, in human plasma. | Journal of chromatography. B, Biomedical sciences and applications.. 1997 Nov 21 702 (1-2) :203-10 | Jayewardene, A L; Santoro, J E; Gambertoglio, J G | 1997 |
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