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| Project Title: | General clinical research center | |
| Principal Investigators (PI): |
DEBAS HAILE T
|
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| Project Number: | 5M01RR000079-34 | |
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | |
| Project Description: | ||
|---|---|---|
| With this renewal, the UCSF General Clinical Research Center begins its 30th year. Our Center is nutritionally focused, supporting a large variety of diet-controlled protocols that result in a high occupancy rate for both inpatient and outpatient studies. Our program is highly diverse by virtue of the variety of nutritional areas supported (carbohydrate, lipid, mineral, acid-base, electrolyte, vitamin D metabolism) and the variety of protocols supported in non-nutritional areas (cardiovascular pharmacology, psychopharmacology, AIDS treatment, allergy, reproductive endocrinology). During the past 5-year grant period, nearly 100 articles resulting from UCSF GCRC studies by 19 different Principal Investigators appeared in print. During the next 5-year period, 17 different Principal Investigators will study: progesterone antagonism of estrogen regulated bone mineral metabolism; circadian rhythms function in elderly; effects of growth hormone and testosterone on vitamin D metabolism in elderly; lipoprotein turnover; psychopharmacology of drug abuse regimens to reverse coronary atherosclerosis; dietary and pharmacological effects on the speciation of high density lipoproteins; effect of prostaglandin inhibition by nonsteroidal anti-inflammatory drugs on bone loss during bed rest in older women; studies of lipoprotein structure in hypo- and hyperlipoproteinemia; diet potassium and hypertension in blacks and elderly; regulation of calcitriol metabolism in health and disease; the effects of aging on calcium blocker kinetics/dynamics; effect of prolonged dietary base supplementation on bone mass in postmenopausal women; effect of age on acid-base homeostasis in normal humans; prophylaxis of Pneumocystis carinii pneumonia in AIDS; dietary cholesterol effects on plasma lipoproteins; postprandial lipid metabolism in coronary artery disease; lipoprotein lipase and hepatic lipase activities in normal and hypertriglyceridemic individuals; neuromediators of allergic rhinopharyngitis; receptor- defective low density lipoproteins; the effect of sulfonylureas on pancreatic beta cell sensitivity; the effect of aging on cardiac R-R variability; noninvasive determination of autonomic regulation of heart rate and AV conduction; effect of anion accompanying diet potassium in treating patients with essential hypertension. By our current projection for the next 5-years, two or more protocols will be devoted to each of the following disorders: hypertension, atherosclerosis, aging, osteoporosis, diabetes mellitus, and AIDS. | ||
| Project Terms: | ||
| There are no related terms in database. | ||
| Project Title: | General clinical research center | |
| Principal Investigators (PI): |
DEBAS HAILE T
|
|
| Project Number: | 5M01RR000079-34 | |
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | |
| Project Categories: | ||
|---|---|---|
|
• Natural Sciences > Metabolism & Nutrition > Dietology |
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| Other Information: | ||
| Fiscal Year: | 1974 | |
| Project Start Date: | 1 December 1974 | |
| Project End Date: | 30 November 1998 | Administering Institute Or Center: | NCRR |
| Project Funding Information: | ||
| Total Funding: | $2,165,418 | |
| Year | Funding Organization | Total Funding, $ |
|---|---|---|
| 1996 | NATIONAL CENTER FOR RESEARCH RESOURCES | $2,165,418 |
| Project Title: | General clinical research center | ||
| Principal Investigators (PI): |
DEBAS HAILE T
|
||
| Project Number: | 5M01RR000079-34 | ||
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | ||
| Project_number | Title | Year | FY Total Cost |
|---|---|---|---|
| There are no results for this project in database. | |||
| Project Title: | General clinical research center | ||
| Principal Investigators (PI): |
DEBAS HAILE T
|
||
| Project Number: | 5M01RR000079-34 | ||
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | ||
| Project number | Project title | Principal investigator | |
|---|---|---|---|
| There are no any related projects. | |||
| Project Title: | General clinical research center | |||
| Principal Investigators (PI): |
DEBAS HAILE T
|
|||
| Project Number: | 5M01RR000079-34 | |||
| Organization: | UNIVERSITY OF CALIFORNIA SAN FRANCISCO | |||
| Title | Abstract | Authors | Year | Rel |
|---|---|---|---|---|
| The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics. | Clinical pharmacology and therapeutics.. 1996 Apr 59 (4) :429-35 | Harris, R Z;Tsunoda, S M;Mroczkowski, P;Wong, H;Benet, L Z | 1996 |
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| Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele. | The Journal of clinical investigation.. 1996 Jan 1 97 (1) :65-72 | Bergeron, N;Havel, R J | 1996 |
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| Effect of aging on the metabolism of phosphorus and 1,25-dihydroxyvitamin D in healthy men. | The American journal of physiology.. 1996 Mar 270 (3 Pt 1) :E483-90 | Portale, A A;Halloran, B P;Morris Jr, R C;Lonergan, E T | 1996 |
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| Aging and renal responsiveness to parathyroid hormone in healthy men. | The Journal of clinical endocrinology and metabolism.. 1996 Jun 81 (6) :2192-7 | Halloran, B P;Lonergan, E T;Portale, A A | 1996 |
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| Single-dose intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime in volunteer subjects. | Antimicrobial agents and chemotherapy.. 1996 Jul 40 (7) :1617-22 | Conte Jr, J E;Golden, J;Duncan, S;McKenna, E;Lin, E;Zurlinden, E | 1996 |
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| Phase II study of paclitaxel in patients with recurrent malignant glioma. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 1996 Aug 14 (8) :2316-21 | Prados, M D;Schold, S C;Spence, A M;Berger, M S;McAllister, L D;Mehta, M P;Gilbert, M R;Fulton, D;Kuhn, J;Lamborn, K;Rector, D J;Chang, S M | 1996 |
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