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| Project Title: | Spore in lung cancer | |
| Principal Investigators (PI): |
BAYLIN STEPHEN B
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| Project Number: | 3P50CA058184-13S1 | |
| Organization: | JOHNS HOPKINS UNIVERSITY | |
| Project Description: | ||
|---|---|---|
| The Johns Hopkins Lung Cancer SPORE is in its tenth year and continues to have as its goals, the performance of highly translational research to move ideas from the bench to bedside, and vice versa, to provide new means for the prevention of, risk assessment for, early detection of, gauging prognosis of, and therapy for, lung cancers of all types. In these efforts, extensive formal collaboration with other Lung Cancer SPORE'S is often emphasized. The program uses the flexibility of the SPORE funding mechanism to extend projects that continually evolve higher and higher translational potential and curtail those that do not. There is an emphasis on constantly bringing in new concepts and directions in parallel with fully evolving those areas that are headed for ultimate translational verification and even reaching common clinical practice. In terms of research at the highest translational level, including work at the population level, the SPORE is presently emphasizing the second and third projects (a collaborative venture with the Colorado SPORE), which are testing epigenetic molecular markers which appear to have very high promise for the areas of risk assessment, early detection, and gauging of prognosis of lung cancer. The first project, also aimed at predicting lung cancer risk and prognosis, is taking new approaches to develop genetic markers for these purposes. A fourth project is developing new concepts for lung cancer prevention by taking the concepts through pre-clinical models and initial proof of principle studies in high risk individuals. This work is very complementary with participation of the Hopkins SPORE in the consortium chemoprevention trials (Lung Cancer Biomarker Chemoprevention Consortium-LCBCC) with the other Lung Cancer SPORES and with a collaborative trial of Iloprost in collaboration with the Colorado SPORE. The fifth and sixth projects are both aimed at development of novel therapeutic strategies for lung cancer with one exploiting new insights into these diseases derived from study of molecular pathways guiding early lung development and the other exploring inhibition of fatty acid synthesis as a new approach. | ||
| Project Terms: | ||
| Area Biologic Marker Biological Markers Cancer of Lung Chemoprevention Ciloprost Clinical Collaborations Colorado Development Development, Other Disease Disorder Early Diagnosis Epigenetic Epigenetic Change Epigenetic Mechanism Epigenetic Process Fatty Acids Flexibility Forecast of outcome Funding Mechanisms Genetic Markers Goals Head Iloprost Individual Malignant Tumor of the Lung Malignant neoplasm of lung Molecular Molecular Marker Pathway interactions Pentanoic acid, 5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)- Performance Pliability Population Pre-Clinical Model Preclinical Models Prevention Prevention of Lung Cancer Prognosis Programs (PT) Programs [Publication Type] Pulmonary Cancer Pulmonary malignant Neoplasm Purpose Reproduction spores Research Risk Risk Assessment Signature Molecule Spores Testing Translational Research Translational Research Enterprise Translational Science Work bench bed side bench bedside bench to bed side bench to bedside biomarker cancer risk collaborative trial concept disease/disorder early detection insight lung cancer lung cancer prevention lung development new approaches new therapeutics next generation therapeutics novel approaches novel strategies novel strategy novel therapeutics outcome forecast pathway programs translation research enterprise | ||
| Project Title: | Spore in lung cancer | |
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
|
| Project Number: | 3P50CA058184-13S1 | |
| Organization: | JOHNS HOPKINS UNIVERSITY | |
| Project Categories: | ||
|---|---|---|
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• Natural Sciences > Aging Diseases and Pathology, Aging mechanisms by anatomy > Cancer & related diseases, Systems level > Malignant neoplasms (including in situ), Reproductive System > Lung cancer |
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| Other Information: | ||
| Fiscal Year: | 1992 | |
| Project Start Date: | 30 September 1992 | |
| Project End Date: | 30 November 2008 | Administering Institute Or Center: | CA |
| Project Funding Information: | ||
| Total Funding: | $1,179,925 | |
| Year | Funding Organization | Total Funding, $ |
|---|---|---|
| 2008 | NATIONAL CANCER INSTITUTE | $1,179,925 |
| Project Title: | Spore in lung cancer | ||
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
||
| Project Number: | 3P50CA058184-13S1 | ||
| Organization: | JOHNS HOPKINS UNIVERSITY | ||
| Project_number | Title | Year | FY Total Cost |
|---|---|---|---|
| There are no results for this project in database. | |||
| Project Title: | Spore in lung cancer | ||
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
||
| Project Number: | 3P50CA058184-13S1 | ||
| Organization: | JOHNS HOPKINS UNIVERSITY | ||
| Project number | Project title | Principal investigator | |
|---|---|---|---|
| There are no any related projects. | |||
| Project Title: | Spore in lung cancer | |||
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
|||
| Project Number: | 3P50CA058184-13S1 | |||
| Organization: | JOHNS HOPKINS UNIVERSITY | |||
| Title | Abstract | Authors | Year | Rel |
|---|---|---|---|---|
| Inhibiting fatty acid synthase for chemoprevention of chemically induced lung tumors. | Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 Apr 15 14 (8) :2458-64 | Orita, Hajime; Coulter, Jonathan; Tully, Ellen; Kuhajda, Francis P; Gabrielson, Edward | 2008 |
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| DNA methylation markers and early recurrence in stage I lung cancer. | The New England journal of medicine. 2008 Mar 13 358 (11) :1118-28 | Brock, Malcolm V; Hooker, Craig M; Ota-Machida, Emi; Han, Yu; Guo, Mingzhou; Ames, Stephen; Glockner, Sabine; Piantadosi, Steven; Gabrielson, Edward; Pridham, Genevieve; Pelosky, Kristen; Belinsky, Steven A; Yang, Stephen C; Baylin, Stephen B; Herman, James G | 2008 |
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| Profiling the expression pattern of GPI transamidase complex subunits in human cancer. | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2008 Aug 21 (8) :979-91 | Nagpal, Jatin K; Dasgupta, Santanu; Jadallah, Sana; Chae, Young K; Ratovitski, Edward A; Toubaji, Antoun; Netto, George J; Eagle, Toby; Nissan, Aviram; Sidransky, David; Trink, Barry | 2008 |
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| Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung. | Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 May 1 14 (9) :2570-8 | Licchesi, Julien D F; Westra, William H; Hooker, Craig M; Herman, James G | 2008 |
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| RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. | Cancer research. 2008 Oct 1 68 (19) :7975-84 | Singh, Anju; Boldin-Adamsky, Swetlana; Thimmulappa, Rajesh K; Rath, Srikanta K; Ashush, Hagit; Coulter, Jonathan; Blackford, Amanda; Goodman, Steven N; Bunz, Fred; Watson, Walter H; Gabrielson, Edward; Feinstein, Elena; Biswal, Shyam | 2008 |
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| Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. | Carcinogenesis. 2008 May 29 (5) :895-904 | Licchesi, Julien D F; Westra, William H; Hooker, Craig M; Machida, Emi O; Baylin, Stephen B; Herman, James G | 2008 |
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| Cancer stem cells and the ontogeny of lung cancer. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2008 Jun 10 26 (17) :2883-9 | Peacock, Craig D; Watkins, D Neil | 2008 |
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