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| Project Title: | Spore in lung cancer | |
| Principal Investigators (PI): |
BAYLIN STEPHEN B
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| Project Number: | 2P50CA058184-09 | |
| Organization: | JOHNS HOPKINS UNIVERSITY | |
| Project Description: | ||
|---|---|---|
| The Johns Hopkins Lung Cancer SPORE is in its tenth year and continues to have as its goals, the performance of highly translational research to move ideas from the bench to bedside, and vice versa, to provide new means for the prevention of, risk assessment for, early detection of, gauging prognosis of, and therapy for, lung cancers of all types. In these efforts, extensive formal collaboration with other Lung Cancer SPORE'S is often emphasized. The program uses the flexibility of the SPORE funding mechanism to extend projects that continually evolve higher and higher translational potential and curtail those that do not. There is an emphasis on constantly bringing in new concepts and directions in parallel with fully evolving those areas that are headed for ultimate translational verification and even reaching common clinical practice. In terms of research at the highest translational level, including work at the population level, the SPORE is presently emphasizing the second and third projects (a collaborative venture with the Colorado SPORE), which are testing epigenetic molecular markers which appear to have very high promise for the areas of risk assessment, early detection, and gauging of prognosis of lung cancer. The first project, also aimed at predicting lung cancer risk and prognosis, is taking new approaches to develop genetic markers for these purposes. A fourth project is developing new concepts for lung cancer prevention by taking the concepts through pre-clinical models and initial proof of principle studies in high risk individuals. This work is very complementary with participation of the Hopkins SPORE in the consortium chemoprevention trials (Lung Cancer Biomarker Chemoprevention Consortium-LCBCC) with the other Lung Cancer SPORES and with a collaborative trial of Iloprost in collaboration with the Colorado SPORE. The fifth and sixth projects are both aimed at development of novel therapeutic strategies for lung cancer with one exploiting new insights into these diseases derived from study of molecular pathways guiding early lung development and the other exploring inhibition of fatty acid synthesis as a new approach. | ||
| Project Terms: | ||
| clinical research neoplasm /cancer chemotherapy cancer prevention lung neoplasms neoplasm /cancer diagnosis molecular oncology | ||
| Project Title: | Spore in lung cancer | |
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
|
| Project Number: | 2P50CA058184-09 | |
| Organization: | JOHNS HOPKINS UNIVERSITY | |
| Project Categories: | ||
|---|---|---|
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• Natural Sciences > Aging Diseases and Pathology > Cancer & related diseases > Malignant neoplasms (including in situ) > Lung cancer |
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| Other Information: | ||
| Fiscal Year: | 1992 | |
| Project Start Date: | 30 September 1992 | |
| Project End Date: | 31 May 2008 | Administering Institute Or Center: | CA |
| Project Funding Information: | ||
| Total Funding: | $2,500,000 | |
| Year | Funding Organization | Total Funding, $ |
|---|---|---|
| 2003 | NATIONAL CANCER INSTITUTE | $2,500,000 |
| Project Title: | Spore in lung cancer | ||
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
||
| Project Number: | 2P50CA058184-09 | ||
| Organization: | JOHNS HOPKINS UNIVERSITY | ||
| Project_number | Title | Year | FY Total Cost |
|---|---|---|---|
| There are no results for this project in database. | |||
| Project Title: | Spore in lung cancer | ||
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
||
| Project Number: | 2P50CA058184-09 | ||
| Organization: | JOHNS HOPKINS UNIVERSITY | ||
| Project number | Project title | Principal investigator | |
|---|---|---|---|
| There are no any related projects. | |||
| Project Title: | Spore in lung cancer | |||
| Principal Investigators (PI): |
BAYLIN STEPHEN B
|
|||
| Project Number: | 2P50CA058184-09 | |||
| Organization: | JOHNS HOPKINS UNIVERSITY | |||
| Title | Abstract | Authors | Year | Rel |
|---|---|---|---|---|
| Gene silencing in cancer in association with promoter hypermethylation. | The New England journal of medicine.. 2003 Nov 20 349 (21) :2042-54 | Herman, James G; Baylin, Stephen B | 2003 |
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| p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study. | Journal of the National Cancer Institute.. 2003 Jul 2 95 (13) :961-70 | Ahrendt, Steven A; Hu, Yingchuan; Buta, Martin; McDermott, Michael P; Benoit, Nicole; Yang, Stephen C; Wu, Li; Sidransky, David | 2003 |
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| Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. | Cancer research.. 2003 Nov 1 63 (21) :7089-93 | Belinsky, Steven A; Klinge, Donna M; Stidley, Christine A; Issa, Jean-Pierre; Herman, James G; March, Thomas H; Baylin, Stephen B | 2003 |
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| Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. | Biochemical and biophysical research communications.. 2003 May 16 304 (4) :605-11 | Wang, Yanlin; Murray-Stewart, Tracy; Devereux, Wendy; Hacker, Amy; Frydman, Benjamin; Woster, Patrick M; Casero Jr, Robert A | 2003 |
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| Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct. | The Biochemical journal.. 2003 Jul 15 373 (Pt 2) :629-34 | Murray-Stewart, Tracy; Applegren, Nancy B; Devereux, Wendy; Hacker, Amy; Smith, Renee; Wang, Yanlin; Casero Jr, Robert A | 2003 |
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| Quantitative GSTP1 methylation clearly distinguishes benign prostatic tissue and limited prostate adenocarcinoma. | The Journal of urology.. 2003 Mar 169 (3) :1138-42 | Harden, Susan V; Guo, Zhongmin; Epstein, Jonathan I; Sidransky, David | 2003 |
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| DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development. | Cancer research. 2003 May 15 63 (10) :2351-7 | Wu, Guojun; Nomoto, Shuji; Hoque, Mohammad Obaidul; Dracheva, Tatiana; Osada, Motonabu; Lee, Chyi-Chia Richard; Dong, Seung Myung; Guo, Zhongmin; Benoit, Nicole; Cohen, Yoram; Rechthand, Peggy; Califano, Joseph; Moon, Chul-So; Ratovitski, Edward; Jen, Jin; Sidransky, David; Trink, Barry | 2003 |
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| Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers. | Cancer research.. 2003 Aug 1 63 (15) :4620-5 | Palmisano, William A; Crume, Kevin P; Grimes, Marcie J; Winters, Sally A; Toyota, Minoru; Esteller, Manel; Joste, Nancy; Baylin, Stephen B; Belinsky, Steven A | 2003 |
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| Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells. | Cancer chemotherapy and pharmacology.. 2003 Nov 52 (5) :383-90 | Devereux, Wendy; Wang, Yanlin; Stewart, Tracy Murray; Hacker, Amy; Smith, Renee; Frydman, Benjamin; Valasinas, Aldonia L; Reddy, Venodhar K; Marton, Laurence J; Ward, Tracey D; Woster, Patrick M; Casero, Robert A | 2003 |
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| Tissue diagnosis of suspected lung cancer: selecting between bronchoscopy, transthoracic needle aspiration, and resectional biopsy. | Respiratory care clinics of North America.. 2003 Mar 9 (1) :51-76 | Yung, Rex C W | 2003 |
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