Myocardial hypertrophy and heart failure

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Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 2P01HL059139-06
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project Description:
Despite recent advances in the treatment of human heart failure, the overall impact on morbidity and mortality has been limited, and heart failure remains the pre-eminent cardiovascular health problem in the country. Limitations in our understanding can be attributed, in part, to the inability to examine basic mechanisms in appropriate animal models in which the progressive pathogenesis of hypertrophy and heart failure can be studied. Thus, the overall aim of this Program Project is to identify physiological, biochemical and molecular mechanisms which are fundamental to the progression from imposition of the abnormal load to development of compensated hypertrophy to heart failure. A secondary goal is to understand the mechanism of potential therapeutic agents within the context of the pathogenesis of hypertrophy and heart failure, focusing on beta-adreriergic blockade therapy. The latter is central to one of the major themes of this Program Project, i.e., alterations in beta-adrenergic and G-protein signaling in hypertrophy and heart failure. To achieve these goals, we will focus primarily on the study of transgenic mice and a novel canine model of heart failure superimposed on chronic, severe cardiac hypertrophy. The organization of the Program Project includes 4 projects and 3 cores. The first Project will examine genomic and proteomic mechanisms of hypertrophy and heart failure utilizing the novel canine model of severe, chronic cardiac hypertrophy with heart failure superimposed. The next Project will emphasizes altered beta-adrenergic receptor signaling and signaling mechanisms involving stress-activated protein kinases in hypertrophy and heart failure. The overall goals of this projectare to elucidate cellular and molecular mechanisms, which may explain the adverse action of enhanced beta-adrenergic receptor signaling in heart failure and conversely, the salutary action of beta-adrenergic receptor blockade therapy. The next Project is designed to provide novel information on molecular mechanisms of adenylyl Cyclase regulation, also, using transgenic models. The final Project will focuses on molecular mechanisms involving Gprotein coupled receptor signaling, e.g., beta-adrenergic and angiotensin receptors in the development of hypertrophy and heart failure. This Program Project will provide significant new information on molecular mechanisms involved in mediating hypertrophy and heart failure, which will also have relevance for understanding corresponding mechanisms in myocardial ischemic disease as well.
 
Project Terms:
heart function heart failure ventricular hypertrophy pathologic process
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 2P01HL059139-06
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project Categories:
• Natural Sciences > Aging Diseases and Pathology, Aging mechanisms by anatomy > Cardiovascular and cerebrovascular diseases, Tissue level > Heart failure, Differentiated tissues > Muscle tissue
 
Other Information:
Fiscal Year: 1997
Project Start Date: 15 September 1997
Project End Date: 29 February 2008
Administering Institute Or Center: HL
 
Project Funding Information:
Total Funding: $1,451,551
Year Funding Organization Total Funding, $
2003 NATIONAL HEART, LUNG, AND BLOOD INSTITUTE $1,451,551
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 2P01HL059139-06
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 2P01HL059139-06
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project number Project title Organization FY Funding Organization FY Total Cost
1T32HL069752-01A2Integrative Mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2004NATIONAL HEART
$229,351
5R01HL033107-21Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2004NATIONAL HEART
$650,750
5P01HL059139-07Myocardial Hypertrophy and Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2004NATIONAL HEART
$1,597,506
5R01HL033107-20Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2003NATIONAL HEART
$635,625
2P01HL059139-06Myocardial Hypertrophy and Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2003NATIONAL HEART
$1,451,551
2R01HL033107-19Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2002NATIONAL HEART
$617,111
5P01HL069020-02-0002Mechanisms underlying short term, chronic and true hiberUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2002NATIONAL HEART
$296,386
5R37HL033107-18CARDIOVASCULAR CONTROL IN NORMAL AND DISEASE STATESUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2001NATIONAL HEART
$574,827
5P01HL059139-05MYCARDIAL HYPERTOPHY AND HEART FAILUREUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2001NATIONAL HEART
$1,780,080
7R37HL033107-17CARDIOVASCULAR CONTROL IN NORMAL AND DISEASE STATESUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2000NATIONAL HEART
$624,461
7R01HL033065-15MYOCARDIAL ISCHEMIA AND CORONARY ARTERY REPERFUSIONUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2000NATIONAL HEART
$375,717
7P01HL059139-04MYCARDIAL HYPERTOPHY AND HEART FAILUREUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2000NATIONAL HEART
$1,746,064
5P01HL069020-10-6Molecular Mechanisms in Chronically Stunned MyocardiumUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$342,976
5P01AG027211-04Longevity and Stress ResistanceUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL INSTITUTE ON AGING
$2,054,477
1R01HL102472-01Intrinsic Vascular Smooth Muscle Cell StiffnessUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$491,296
1P20HL101420-01AC5 Inhibitor Treatment for Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2010NATIONAL HEART
$779,111
5P01HL059139-08Myocardial Hypertrophy and Heart FailureUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2005NATIONAL HEART
$1,971,977
5P01HL069020-05-0002Mechanisms underlying short term, chronic and true hiberUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2005NATIONAL HEART
$322,754
5R01HL033107-22Cardiovascular Control in Normal and Disease StatesUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2005NATIONAL HEART
$665,935
5T32HL069752-02Integrative Mechanisms in Cardiovascular DiseaseUNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL2005NATIONAL HEART
$458,703
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 2P01HL059139-06
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Myocardial hypertrophy and heart failure
Principal Investigators (PI): VATNER STEPHEN F
Project Number: 2P01HL059139-06
Organization: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
 
Title Abstract Authors Year Rel
Mesenteric lymph from rats with thermal injury prolongs the action potential and increases Ca2+ transient in rat ventricular myocytes. Shock (Augusta, Ga.). 2003 Nov 20 (5) :458-64 Yatani, Atsuko; Xu, Da-Zhong; Kim, Song-Jung; Vatner, Stephen F; Deitch, Edwin A 2003
Cardiac nerves affect myocardial stunning through reactive oxygen and nitric oxide mechanisms. Circulation research.. 2003 Oct 31 93 (9) :866-73 Huang, Cheng-Hsiung; Vatner, Stephen F; Peppas, Athanasios P; Yang, Guiping; Kudej, Raymond K 2003
Ischemic preconditioning prevents ischemia-induced beta-adrenergic receptor sequestration. Journal of molecular and cellular cardiology.. 2003 Aug 35 (8) :923-9 Iwatsubo, Kousaku; Toya, Yoshiyuki; Fujita, Takayuki; Ebina, Toshiaki; Schwencke, Carsten; Minamisawa, Susumu; Umemura, Satoshi; Ishikawa, Yoshihiro 2003
Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts. American journal of physiology. Cell physiology.. 2003 Sep 285 (3) :C567-74 Oshikawa, Jin; Toya, Yoshiyuki; Fujita, Takayuki; Egawa, Masato; Kawabe, Junichi; Umemura, Satoshi; Ishikawa, Yoshihiro 2003
Isoform-specific regulation of adenylyl cyclase: a potential target in future pharmacotherapy. Expert opinion on therapeutic targets.. 2003 Jun 7 (3) :441-51 Iwatsubo, Kousaku; Tsunematsu, Takashi; Ishikawa, Yoshihiro 2003
Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation.. 2003 Dec 9 108 (23) :2926-33 Gaussin, Vinciane; Tomlinson, James E; Depre, Christophe; Engelhardt, Stefan; Antos, Christopher L; Takagi, Gen; Hein, Lutz; Topper, James N; Liggett, Stephen B; Olson, Eric N; Lohse, Martin J; Vatner, Stephen F; Vatner, Dorothy E 2003
Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. The Journal of biological chemistry.. 2003 Nov 28 278 (48) :47622-8 Kim, Young-Kwon; Kim, Song-Jung; Yatani, Atsuko; Huang, Yanhong; Castelli, Germana; Vatner, Dorothy E; Liu, Jing; Zhang, Qizhi; Diaz, Gissela; Zieba, Renata; Thaisz, Jill; Drusco, Alessandra; Croce, Carlo; Sadoshima, Junichi; Condorelli, Gianluigi; Vatner, Stephen F 2003
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. The Journal of clinical investigation.. 2003 May 111 (10) :1463-74 Yamamoto, Shimako; Yang, Guiping; Zablocki, Daniela; Liu, Jing; Hong, Chull; Kim, Song-Jung; Soler, Sandra; Odashima, Mari; Thaisz, Jill; Yehia, Ghassan; Molina, Carlos A; Yatani, Atsuko; Vatner, Dorothy E; Vatner, Stephen F; Sadoshima, Junichi 2003
Motor dysfunction in type 5 adenylyl cyclase-null mice. The Journal of biological chemistry.. 2003 May 9 278 (19) :16936-40 Iwamoto, Tamio; Okumura, Satoshi; Iwatsubo, Kousaku; Kawabe, Jun-Ichi; Ohtsu, Koji; Sakai, Ikuko; Hashimoto, Yoko; Izumitani, Aki; Sango, Kazunori; Ajiki, Kyoko; Toya, Yoshiyuki; Umemura, Satoshi; Goshima, Yoshio; Arai, Nobutaka; Vatner, Stephen F; Ishikawa, Yoshihiro 2003
Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation. Circulation research.. 2003 Aug 22 93 (4) :364-71 Okumura, Satoshi; Kawabe, Jun-ichi; Yatani, Atsuko; Takagi, Gen; Lee, Ming-Chih; Hong, Chull; Liu, Jing; Takagi, Ikuyo; Sadoshima, Junichi; Vatner, Dorothy E; Vatner, Stephen F; Ishikawa, Yoshihiro 2003
Gender differences on the effects of aging on cardiac and peripheral adrenergic stimulation in old conscious monkeys. American journal of physiology. Heart and circulatory physiology.. 2003 Aug 285 (2) :H527-34 Takagi, Gen; Asai, Kuniya; Vatner, Stephen F; Kudej, Raymond K; Rossi, Franco; Peppas, Athanasios; Takagi, Ikuyo; Resuello, Ranillo R G; Natividad, Filipinas; Shen, You-Tang; Vatner, Dorothy E 2003
Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. American journal of physiology. Heart and circulatory physiology.. 2003 Apr 284 (4) :H1043-7 Morisco, Carmine; Sadoshima, Junichi; Trimarco, Bruno; Arora, Rohit; Vatner, Dorothy E; Vatner, Stephen F 2003
Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms. Circulation research.. 2003 Jun 13 92 (11) :1233-9 Kim, Song-Jung; Peppas, Athanasios; Hong, Suk-Keun; Yang, Guiping; Huang, Yanhong; Diaz, Gissela; Sadoshima, Junichi; Vatner, Dorothy E; Vatner, Stephen F 2003
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. The Journal of clinical investigation.. 2003 Nov 112 (9) :1395-406 Yamamoto, Mitsutaka; Yang, Guiping; Hong, Chull; Liu, Jing; Holle, Eric; Yu, Xianzhong; Wagner, Thomas; Vatner, Stephen F; Sadoshima, Junichi 2003
Characterization of pDJA1, a cardiac-specific chaperone found by genomic profiling of the post-ischemic swine heart. Cardiovascular research.. 2003 Apr 1 58 (1) :126-35 Depre, Christophe; Wang, Li; Tomlinson, James E; Gaussin, Vinciane; Abdellatif, Maha; Topper, James N; Vatner, Stephen F 2003
Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy. Cardiovascular research.. 2003 Sep 1 59 (3) :649-57 Li, Joan; Yatani, Atsuko; Kim, Song-Jung; Takagi, Gen; Irie, Keiichi; Zhang, Qizhi; Karoor, Vijaya; Hong, Chull; Yang, Guiping; Sadoshima, Junichi; Depre, Christophe; Vatner, Dorothy E; West, Malcolm J; Vatner, Stephen F 2003
Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circulation research.. 2003 Jul 11 93 (1) :12-22 Tomita, Hideharu; Nazmy, Michael; Kajimoto, Katsuya; Yehia, Ghassan; Molina, Carlos A; Sadoshima, Junichi 2003
Nitric oxide-dependent vasodilation maintains blood flow in true hibernating myocardium. Journal of molecular and cellular cardiology.. 2003 Aug 35 (8) :931-5 Kudej, Raymond K; Vatner, Stephen F 2003
Novel mechanisms mediating stunned myocardium. Heart failure reviews.. 2003 Apr 8 (2) :143-53 Kim, Song-Jung; Depre, Christophe; Vatner, Stephen F 2003
Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proceedings of the National Academy of Sciences of the United States of America.. 2003 Aug 19 100 (17) :9986-90 Okumura, Satoshi; Takagi, Gen; Kawabe, Jun-ichi; Yang, Guiping; Lee, Ming-Chih; Hong, Chull; Liu, Jing; Vatner, Dorothy E; Sadoshima, Junichi; Vatner, Stephen F; Ishikawa, Yoshihiro 2003
Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy. Journal of cardiovascular pharmacology. 2003 Dec 42 Suppl 1 () :S27-32 Ikoma, Eiko; Tsunematsu, Takashi; Nakazawa, Ichirou; Shiwa, Tadashi; Hibi, Kiyoshi; Ebina, Toshiaki; Mochida, Yasuyuki; Toya, Yoshiyuki; Hori, Hideaki; Uchino, Kazuaki; Minamisawa, Susumu; Kimura, Kazuo; Umemura, Satoshi; Ishikawa, Yoshihiro 2003