Neural regulation of pancreatic function

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Project Title: Neural regulation of pancreatic function
Principal Investigators (PI): DEBAS HAILE T
Project Number: 1R01DK046285-01
Organization: UNIVERSITY OF CALIFORNIA SAN FRANCISCO
 
Project Description:
Complex interactions between nerves and hormones regulate pancreatic exocrine secretion. Peptidergic neurones are an important component of the vagal, sympathetic, sensory and intrinsic innervation of the pancreas. The peptides are synthesized and transported by these nerves and serve as important neurotransmitters. Examination of the role of neuropeptides in the regulation of pancreatic exocrine secretion has been hampered because specific antagonists were not available. Although neuropeptides almost certainly participate in the enteropancreatic reflex, by which food in the intestine induces pancreatic secretion, the relative importance of neural and humoral pathways in this reflex is unknown because satisfactory models for complete extrinsic denervation were lacking. We now have specific antagonists for neuropeptides and can successfully transplant the jejunum to achieve total extrinsic denervation. We propose, therefore, three specific aims which will elucidate the role of neuropeptides in the neural control of pancreatic exocrine secretion. Specific aim I examines the contribution of peptidergic neurones to the vagal control of pancreatic secretion by using specific antagonists to cholecystokinin, vasoactive intestinal polypeptide, gastrin releasing peptide and somatostatin; these peptides are contained in vagal as well as in intrinsic pancreatic neurones. Specific aim II examines the role of the sensory innervation of the pancreas in two ways. Firstly, low doses of the sensory neurotoxin, capsaicin, will be administered to the isolated, vascularly-perfused pancreas to release neuropeptides (calcitonin gene-related peptide and substance P) from sensory nerve fibers. Secondly, the sensory innervation of the pancreas will be ablated by the chronic administration of high doses of capsaicin. The consequences of these treatments to pancreatic exocrine secretion will be studies. Specific aim III examines the importance of enteropancreatic reflexes by small intestinal transplantation, a well- established technique in our laboratory. By this technique and by using specific antagonists of cholecystokinin, secretin, vasoactive intestinal polypeptide an gastrin releasing peptide we will be able to determine the mechanism by which intestinal nutrients stimulate pancreatic secretion. The proposed work has important application to our understanding of human pancreatic diseases and to their treatment by surgical intervention and transplantation.
 
Project Terms:
acinar cell pancreas vagus nerve hormone regulation /control mechanism gastrointestinal function C fiber atropine caseins calcitonin gene related peptide gastrointestinal transplantation gastrointestinal pharmacology secretion amylases hormone inhibitor oleate jejunum substance P pancreatic juice vasoactive intestinal peptide neuropeptide receptor capsaicin denervation laboratory rat electrostimulus isolation perfusion
Project Title: Neural regulation of pancreatic function
Principal Investigators (PI): DEBAS HAILE T
Project Number: 1R01DK046285-01
Organization: UNIVERSITY OF CALIFORNIA SAN FRANCISCO
 
Project Categories:
• Natural Sciences > Aging Diseases and Pathology > Cancer & related diseases > Malignant neoplasms (including in situ) > Gastrointestinal cancers > Pancreatic Cancer
 
Other Information:
Fiscal Year: 1994
Project Start Date: 15 May 1994
Project End Date: 30 April 1997
Administering Institute Or Center: NIDDK
 
Project Funding Information:
Total Funding: $126,426
Year Funding Organization Total Funding, $
1994 NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES $126,426
Project Title: Neural regulation of pancreatic function
Principal Investigators (PI): DEBAS HAILE T
Project Number: 1R01DK046285-01
Organization: UNIVERSITY OF CALIFORNIA SAN FRANCISCO
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Neural regulation of pancreatic function
Principal Investigators (PI): DEBAS HAILE T
Project Number: 1R01DK046285-01
Organization: UNIVERSITY OF CALIFORNIA SAN FRANCISCO
 
Project number Project title Organization FY Funding Organization FY Total Cost
5R01DK037173-07INHIBITORY MECHANISMS OF THE GASTRIC FUNDUSUNIVERSITY OF CALIFORNIA SAN FRANCISCO1992NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$147,813
5T32DK007573-05RESEARCH TRAINING IN GASTROINTESTINAL SURGERYUNIVERSITY OF CALIFORNIA SAN FRANCISCO1992NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$97,473
3T32DK007573-05S1RESEARCH TRAINING IN GASTROINTESTINAL SURGERYUNIVERSITY OF CALIFORNIA SAN FRANCISCO1992NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$33,696
5R01DK037173-08INHIBITORY MECHANISMS OF THE GASTRIC FUNDUSUNIVERSITY OF CALIFORNIA SAN FRANCISCO1993NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$183,781
2T32DK007573-06RESEARCH TRAINING IN GASTROINTESTINAL SURGERYUNIVERSITY OF CALIFORNIA SAN FRANCISCO1993NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$97,751
5R01DK037173-09INHIBITORY MECHANISMS OF THE GASTRIC FUNDUSUNIVERSITY OF CALIFORNIA SAN FRANCISCO1994NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$180,708
1R01DK046285-01NEURAL REGULATION OF PANCREATIC FUNCTIONUNIVERSITY OF CALIFORNIA SAN FRANCISCO1994NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$126,426
5T32DK007573-07RESEARCH TRAINING IN GASTROINTESTINAL SURGERYUNIVERSITY OF CALIFORNIA SAN FRANCISCO1994NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$91,912
2M01RR000079-33GENERAL CLINICAL RESEARCH CENTERUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL CENTER FOR RESEARCH RESOURCES
$1,687,891
5M01RR000083-33GENERAL CLINICAL RESEARCH CENTERUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL CENTER FOR RESEARCH RESOURCES
$458,660
3M01RR001271-14S2GENERAL CLINICAL RESEARCH CENTERUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL CENTER FOR RESEARCH RESOURCES
$198,555
3R01DK046285-02S1NEURAL REGULATION OF PANCREATIC FUNCTIONUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$15,134
3T32DK007573-07S1RESEARCH TRAINING IN GASTROINTESTINAL SURGERYUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$34,212
3T32DK007573-08S1RESEARCH TRAINING IN GASTROINTESTINAL SURGERYUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$35,479
5T32DK007573-08RESEARCH TRAINING IN GASTROINTESTINAL SURGERYUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$101,622
5R01DK046285-02NEURAL REGULATION OF PANCREATIC FUNCTIONUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
$115,445
3M01RR001271-14S1GCRC-CAP-DR ELDERUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL CENTER FOR RESEARCH RESOURCES
$35,760
5M01RR001271-14GENERAL CLINICAL RESEARCH CENTERUNIVERSITY OF CALIFORNIA SAN FRANCISCO1995NATIONAL CENTER FOR RESEARCH RESOURCES
$1,570,000
5M01RR000079-34GENERAL CLINICAL RESEARCH CENTERUNIVERSITY OF CALIFORNIA SAN FRANCISCO1996NATIONAL CENTER FOR RESEARCH RESOURCES
$2,165,418
5M01RR000083-34GENERAL CLINICAL RESEARCH CENTERUNIVERSITY OF CALIFORNIA SAN FRANCISCO1996NATIONAL CENTER FOR RESEARCH RESOURCES
$1,681,400
Project Title: Neural regulation of pancreatic function
Principal Investigators (PI): DEBAS HAILE T
Project Number: 1R01DK046285-01
Organization: UNIVERSITY OF CALIFORNIA SAN FRANCISCO
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Neural regulation of pancreatic function
Principal Investigators (PI): DEBAS HAILE T
Project Number: 1R01DK046285-01
Organization: UNIVERSITY OF CALIFORNIA SAN FRANCISCO
 
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