Transgenic animal core

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Project Title: Transgenic animal core
Principal Investigators (PI): RICHARDSON ARLAN G
Project Number: 1P01AG020591-01-9002
Parent Project: 1P01AG020591-01
Organization: UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT
 
Project Description:
The Transgenic Animal Core will provide investigators in the three Projects with uniformly maintained, specific-pathogen-free colonies of aging knockout/transgenic mice with alterations in genes coding for either Mn-superoxide dismutase (Sod2) or Cu/Zn-superoxide dismutase (Sod1). In addition, the Transgenic Animal Core will generate conditional knockout mice for Sod2 in which the skeletal muscle is null for MnSOD (Sod2D3-/- mice). The following knockout/transgenic mouse models and their wild type littermates will be maintained in the Transgenic Animal Core: 1) MnSOD heterozygous (Sod2+/-), knockout mice, 2) MnSOD conditional homozygous (Sod2D3-/-) knockout mice, 3) transgenic mice over-expressing MnSOD (SodTg+/o), and 4) Cu/ZnSOD heterozygous (Sod1+/-) and homozygous (Sod1-/-) mice. The specific aims of the Transgenic Animal Core are as follows: 1. To produce conditional knockout mice (Sod2D3-/-) that do not express MnSOD in skeletal muscle. 2. To maintain breeding colonies of the transgenic mice to produce female knockout/transgenic mice used in this study by the three Projects. 3. To maintain aging colonies of female knockout/transgenic and wild type control mice. Animals from these colonies will be used by the investigators in three Projects for the experiments described in this proposal.
 
Project Terms:
gene targeting animal breeding biomedical facility genetically modified animals animal colony laboratory mouse superoxide dismutase aging striated muscles
Project Title: Transgenic animal core
Principal Investigators (PI): RICHARDSON ARLAN G
Project Number: 1P01AG020591-01-9002
Parent Project: 1P01AG020591-01
Organization: UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT
 
Project Categories:
• Natural Sciences > Aging Diseases and Pathology, Model organisms > Neurodegenerative diseases, Multicellular > Amyotrophic lateral sclerosis, Fly
 
Other Information:
Fiscal Year: 2002
Project Start Date: 1 April 2002
Project End Date: 31 March 2007
Administering Institute Or Center: AG
 
Project Funding Information:
Total Funding: $171,586
Year Funding Organization Total Funding, $
2002 NATIONAL INSTITUTE ON AGING $171,586
Project Title: Transgenic animal core
Principal Investigators (PI): RICHARDSON ARLAN G
Project Number: 1P01AG020591-01-9002
Parent Project: 1P01AG020591-01
Organization: UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT
 
Project_number Title Year FY Total Cost
There are no results for this project in database.
Project Title: Transgenic animal core
Principal Investigators (PI): RICHARDSON ARLAN G
Project Number: 1P01AG020591-01-9002
Parent Project: 1P01AG020591-01
Organization: UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT
 
Project number Project title Organization FY Funding Organization FY Total Cost
5R13AG012917-10Summer Training Courses in Aging ResearchUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2004NATIONAL INSTITUTE ON AGING
$35,393
5R01AG023843-02Role of Oxidative Damage to Specific Molecules in AgingUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2004NATIONAL INSTITUTE ON AGING
$330,500
3R01AG023843-02S1Role of Oxidative Damage to Specific Molecules in AgingUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2004NATIONAL INSTITUTE ON AGING
$124,500
5P30AG013319-10NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2004NATIONAL INSTITUTE ON AGING
$1,077,539
3P30AG013319-10S1NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2004NATIONAL INSTITUTE ON AGING
$81,750
2R13AG012917-09Summer Training Courses in Aging ResearchUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2003NATIONAL INSTITUTE ON AGING
$41,448
1R01AG023843-01Role of Oxidative Damage to Specific Molecules in AgingUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2003NATIONAL INSTITUTE ON AGING
$342,000
3P30AG013319-09S2NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2003NATIONAL INSTITUTE ON AGING
$122,000
3P30AG013319-09S3NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2003NATIONAL INSTITUTE ON AGING
$48,067
3P30AG013319-09S1NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2003NATIONAL INSTITUTE ON AGING
$78,000
5P30AG013319-09NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2003NATIONAL INSTITUTE ON AGING
$990,892
3P01AG014674-05S1NUTRITIONAL PROBE OF THE AGING PROCESSUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2003NATIONAL INSTITUTE ON AGING
$54,020
3P30AG013319-08S1NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2002NATIONAL INSTITUTE ON AGING
$141,500
5P30AG013319-08NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2002NATIONAL INSTITUTE ON AGING
$829,990
3P30AG013319-08S2NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2002NATIONAL INSTITUTE ON AGING
$105,000
1P01AG020591-01-9002TRANSGENIC ANIMAL COREUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2002NATIONAL INSTITUTE ON AGING
$171,586
5P01AG014674-05NUTRITIONAL PROBE OF THE AGING PROCESSUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2002NATIONAL INSTITUTE ON AGING
$1,323,400
5R01AG015908-04TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGEUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2001NATIONAL INSTITUTE ON AGING
$174,415
5P30AG013319-07NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2001NATIONAL INSTITUTE ON AGING
$860,819
3P30AG013319-07S1NATHAN SHOCK AGING CENTERUNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT2001NATIONAL INSTITUTE ON AGING
$223,100
Project Title: Transgenic animal core
Principal Investigators (PI): RICHARDSON ARLAN G
Project Number: 1P01AG020591-01-9002
Parent Project: 1P01AG020591-01
Organization: UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Transgenic animal core
Principal Investigators (PI): RICHARDSON ARLAN G
Project Number: 1P01AG020591-01-9002
Parent Project: 1P01AG020591-01
Organization: UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT
 
Title Abstract Authors Year Rel